2-(3-bromophenyl)-2,2-difluoroacetic acid

Base Information

• Chemical Name: 2-(3-bromophenyl)-2,2-difluoroacetic acid
• CAS No.: 885068-76-8
• Molecular Formula: C₈H₅BrF₂O₂
• Molecular Weight: 251.027
• Hs Code.: 2916399090
• Mol file: 885068-76-8.mol

Synonyms:methyl 2-(3-bromophenyl)-2,2-difluoroacetate

Chemical Property of 2-(3-bromophenyl)-2,2-difluoroacetic acid

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Bromophenyl)-2,2-difluoroacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-bromophenyl)-2,2-difluoroacetic acid

There total 3 articles about 2-(3-bromophenyl)-2,2-difluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 2-(3-bromophenyl)acetatee (150529-73-0) → methyl 2-(3-bromophenyl)-2,2-difluoroacetate (885068-76-8)

Guidance literature:

methyl 2-(3-bromophenyl)acetatee; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.416667h;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; for 3.58333h;

Reference yield: 95.0%

→ methyl 2-(3-bromophenyl)-2,2-difluoroacetate (885068-76-8)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

1-Bromo-3-iodobenzene (591-18-4) → methyl 2-(3-bromophenyl)-2,2-difluoroacetate (885068-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper / dimethyl sulfoxide / 12 h / 60 °C / Inert atmosphere

2: sodium hydroxide / ethanol / 12 h / 20 °C

With copper; sodium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1039/d0ob02546a

upstream raw materials:

methyl 2-(3-bromophenyl)acetatee

1-Bromo-3-iodobenzene

Downstream raw materials:

3-(difluoro-acetic acid)phenyl boronic acid

2-(4'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetic acid

(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid