(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid

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Chemical Name:(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid
CAS No.:885068-74-6
Molecular Formula:C₂₁H₁₇Cl₂F₂N₃O₃
Molecular Weight:468.287
Hs Code.:

Synonyms:(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid

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Chemical Property of (3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid

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Technology Process of (3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid

There total 5 articles about (3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885068-77-9
3-(difluoro-acetic acid)phenyl boronic acid

: 1016644-41-9
(6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(2,4-dichloro-phenyl)-ethyl]-amine

: 885068-74-6
(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid

Guidance literature:: 3-(difluoro-acetic acid)phenyl boronic acid; (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(2,4-dichloro-phenyl)-ethyl]-amine; With caesium carbonate; In 1,2-dimethoxyethane; water; for 0.166667h;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; Heating / reflux;

With hydrogenchloride; In water; pH=4 - 5; Acidic aqueous solution;

Reference yield:

: 885068-76-8
methyl 2-(3-bromophenyl)-2,2-difluoroacetate

: 885068-74-6
(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

1.2: 1.5 h

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 90 °C / Heating / reflux

With n-butyllithium; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; pentane;

Reference yield:

: 885068-75-7
2-(3-bromophenyl)-2,2-difluoroacetic acid ethyl ester

: 885068-74-6
(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-difluoro-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / methanol / 20 °C

2.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

2.2: 1.5 h

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 90 °C / Heating / reflux

With lithium hydroxide; n-butyllithium; water; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; pentane;