desepoxy-3-epicryptophycin-24

Base Information

Chemical Name:desepoxy-3-epicryptophycin-24
CAS No.:728032-77-7
Molecular Formula:C₃₄H₄₂N₂O₇
Molecular Weight:590.717
Hs Code.:

Synonyms:desepoxy-3-epicryptophycin-24

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Chemical Property of desepoxy-3-epicryptophycin-24

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Technology Process of desepoxy-3-epicryptophycin-24

There total 9 articles about desepoxy-3-epicryptophycin-24 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 728032-77-7
desepoxy-3-epicryptophycin-24

Guidance literature:: Multi-step reaction with 8 steps

1.1: 76 percent / K₂CO₃; tetrabutylammonium iodide / dimethylformamide / 1.5 h / 20 °C

2.1: 90 percent / DMAP; DCC / CH₂Cl₂ / 19.5 h / 0 - 20 °C

3.1: TFA / CH₂Cl₂ / 3.5 h / 20 °C

4.1: 1.47 g / HOBT; DIEA; DCC / tetrahydrofuran / 16.5 h / 0 - 20 °C

5.1: 95 percent / H₂ / Pd(OH)2 / ethyl acetate / 2 h

6.1: DIEA; 2,4,6-trichlorobenzoyl chloride; DMAP / tetrahydrofuran / 2 h / 0 °C

6.2: 85 percent / tetrahydrofuran / 2 h / 20 °C

7.1: CH₂Cl₂ / 2 h / 20 °C

8.1: 0.043 g / DIEA; HBTU / acetonitrile / 3 h / 20 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030555f

Reference yield:

: (2E,7E)-(5S,6R)-5-((R)-2-{3-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoyloxy)-6-methyl-8-phenyl-octa-2,7-dienoic acid; compound with trifluoro-acetic acid

: 728032-77-7
desepoxy-3-epicryptophycin-24

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1021/jm030555f

Reference yield:

: 37755-48-9
benzyl (R)-2-hydroxy-4-methylpentanoate

: 728032-77-7
desepoxy-3-epicryptophycin-24

Guidance literature:: Multi-step reaction with 7 steps

1.1: 90 percent / DMAP; DCC / CH₂Cl₂ / 19.5 h / 0 - 20 °C

2.1: TFA / CH₂Cl₂ / 3.5 h / 20 °C

3.1: 1.47 g / HOBT; DIEA; DCC / tetrahydrofuran / 16.5 h / 0 - 20 °C

4.1: 95 percent / H₂ / Pd(OH)2 / ethyl acetate / 2 h

5.1: DIEA; 2,4,6-trichlorobenzoyl chloride; DMAP / tetrahydrofuran / 2 h / 0 °C

5.2: 85 percent / tetrahydrofuran / 2 h / 20 °C

6.1: CH₂Cl₂ / 2 h / 20 °C

7.1: 0.043 g / DIEA; HBTU / acetonitrile / 3 h / 20 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm030555f