Technology Process of cis-7-acetoxy-6,7-dihydro-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine
There total 7 articles about cis-7-acetoxy-6,7-dihydro-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium acetate;
at 85 ℃;
for 7h;
Heating;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodium, ethanol / 1.) 15 min., 2.) THF, 60 deg C, 5h
2: 92 percent / NaOH / aq. ethanol / 5 h / Heating
3: 1.) PCl5, 2.) AlCl3 / 1.) CS2, 65 deg C, 6h, 2.) CH2Cl2, 55-60 deg C, 23h
4: 73 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating
5: 20 percent / sodium acetate / 7 h / 85 °C / Heating
With
sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; ethanol; phosphorus pentachloride; sodium acetate; sodium;
In
tetrahydrofuran; ethanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 78 percent / N-bromosucchinimide / CCl4 / 25 h / Heating
2: 1.) sodium, ethanol / 1.) 15 min., 2.) THF, 60 deg C, 5h
3: 92 percent / NaOH / aq. ethanol / 5 h / Heating
4: 1.) PCl5, 2.) AlCl3 / 1.) CS2, 65 deg C, 6h, 2.) CH2Cl2, 55-60 deg C, 23h
5: 73 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating
6: 20 percent / sodium acetate / 7 h / 85 °C / Heating
With
sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; aluminium trichloride; ethanol; phosphorus pentachloride; sodium acetate; sodium;
In
tetrahydrofuran; tetrachloromethane; ethanol;
