N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide

Base Information

Chemical Name:N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide
CAS No.:1426095-26-2
Molecular Formula:C₂₅H₃₀N₂O₂
Molecular Weight:390.525
Hs Code.:

Synonyms:N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide

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Chemical Property of N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide

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Technology Process of N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide

There total 9 articles about N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426095-87-5
N-(1-methylethyl)-N-(3-pyrrolidinylmethyl)-4-biphenylcarboxamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1426095-26-2
N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 270912-72-6
tert-butyl 3-(aminomethyl)pyrrolidine-1-carboxylate

: 1426095-26-2
N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,2-dichloro-ethane / 18 h

1.2: 18 h

2.1: triethylamine / tetrahydrofuran / 1 h

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane;

Reference yield:

: 93138-61-5
C-(1-benzyl-pyrrolidin-3-yl)-methylamine

: 1426095-26-2
N-{[(3RS)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 12 h / 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen; palladium(II) hydroxide; acetic acid / methanol / 48 h / 20 °C

3.1: triethylamine / methanol / 0.5 h / 0 °C

3.2: 24 h / 0 - 20 °C

4.1: sodium hydroxide / methanol; water / 3 h / 20 °C

5.1: 1,2-dichloro-ethane / 18 h

5.2: 18 h

6.1: triethylamine / tetrahydrofuran / 1 h

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; palladium(II) hydroxide; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane;