1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate
CAS No.:937175-02-5
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate

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Chemical Property of 1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate

Chemical Property:

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Technology Process of 1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate

There total 7 articles about 1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 937175-01-4
(6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}morpholine

: 24424-99-5
di-tert-butyl dicarbonate

: 937175-02-5
1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate

Guidance literature:: In acetonitrile; at 20 ℃;

Reference yield:

: 937174-97-5
(S)-1-(benzyloxy)-3-((2,4-dimethoxybenzyl)amino)propan-2-ol

: 937175-02-5
1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 1.5 h / 20 °C

4.1: dichloromethane / 2 h / 20 °C / Heating / reflux

5.1: methanol / 1 h / Heating / reflux

6.1: acetonitrile / 20 °C

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 937174-99-7
(6R)-4-{[2,4-bis(methyloxy)phenyl]methyl}-2-methyl-6-{[(phenylmethyl)oxy]methyl}-3-morpholinone

: 937175-02-5
1,1-dimethylethyl (6R)-2-methyl-6-{[(phenylmethyl)oxy]methyl}-4-morpholinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 20 °C

1.2: 1.5 h / 20 °C

2.1: dichloromethane / 2 h / 20 °C / Heating / reflux

3.1: methanol / 1 h / Heating / reflux

4.1: acetonitrile / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;