((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Base Information

• Chemical Name: ((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone
• CAS No.: 188806-86-2
• Molecular Formula: C₂₄H₂₉N₃O₄S₂
• Molecular Weight: 487.644

Synonyms:((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Chemical Property of ((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

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Technology Process of ((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

There total 1 articles about ((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

acrylcamphorsultam (94594-91-9) + (Z)-N-(2-thiazolyl)methylenebenzylamine N-oxide (162365-53-9,162740-09-2) → ((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (188806-86-2) + ((3S,5S)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (188806-95-3)

Guidance literature:

In dichloromethane; for 120h; Heating;

DOI:10.1016/S0040-4020(97)00040-9

Reference yield: 96.0%

((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (188806-86-2) → (3R,5R)-1-benzyl-3-hydroxy-5-(2-thiazolyl)-2-pyrrolidinone (188807-13-8)

Guidance literature:

With zinc; In tetrahydrofuran; water; acetic acid; at 60 ℃; for 5h;

DOI:10.1016/S0040-4020(97)00040-9

Reference yield: 70.0%

((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (188806-86-2) → ((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-methanol (188807-33-2) + (2R)-bornane-10,2-sultam (94594-90-8,124224-04-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.25h;

DOI:10.1016/S0040-4020(97)00040-9

upstream raw materials:

acrylcamphorsultam

(Z)-N-(2-thiazolyl)methylenebenzylamine N-oxide

Downstream raw materials:

(3R,5R)-1-benzyl-3-hydroxy-5-(2-thiazolyl)-2-pyrrolidinone

((3R,5R)-2-Benzyl-3-thiazol-2-yl-isoxazolidin-5-yl)-methanol

(2R)-bornane-10,2-sultam

(3R,5R)-3-acetoxy-1-benzyl-c-5-(2-thiazolyl)-2-pyrrolidinone

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