94594-91-9

Basic information

• Product Name: Oppolzer's caMphor sultaM
• Synonyms: Oppolzer's caMphor sultaM;(R)-(-)-Acryloyl-2,10-camphorsultam
• CAS NO: 94594-91-9
• Molecular Formula: C₁₃H₁₉NO₃S
• Molecular Weight: 269.35986
• EINECS: -0
• Mol File: 94594-91-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 203-205 °C(Solv: ethanol (64-17-5))
• Boiling Point: 382.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.29±0.1 g/cm3(Predicted)
• PKA: -14.54±0.40(Predicted)
• CAS DataBase Reference: Oppolzer's caMphor sultaM(CAS DataBase Reference)
• NIST Chemistry Reference: Oppolzer's caMphor sultaM(94594-91-9)
• EPA Substance Registry System: Oppolzer's caMphor sultaM(94594-91-9)

Safety Data

• Hazardous Substances Data: 94594-91-9(Hazardous Substances Data)

Usage

General Description

Oppolzer's camphor sulfam is a chiral reagent used in asymmetric synthesis, particularly in the field of organic chemistry. It is a highly valuable compound in the production of Pharmaceuticals and agrochemicals. Due to its exceptional properties, it is widely used as a building block in the synthesis of bioactive compounds and pharmaceutical intermediates. Oppolzer's caMphor sultaM is known for its ability to facilitate chiral transformations with high enantioselectivity, making it an essential tool for the development of new drugs and other biologically active molecules. Oppolzer's camphor sulfam has proven to be a versatile and effective reagent in the field of organic synthesis, playing a critical role in the advancement of medicinal and chemical research.

Upstream product

• 814-68-6 acryloyl chloride 
• 167934-73-8 N-trimethylsilylbornane-10,2-sultam 
• 119897-86-8 N-<(4,5-dihydro-3-ethyl-(5R)-5-isoxazolyl)carbonyl>-(2R)-bornane-10,2-sultam 
• 119897-85-7 N-<(4,5-dihydro-3-methyl-(5R)-5-isoxazolyl)carbonyl>-(2R)-bornane-10,2-sultam 
• 3144-16-9 (1S)-10-camphorsulfonic acid 
• 17854-63-6 (+/-)-2-oxo-bornane-10-sulfonic acid amide 
• 2051-76-5 acrylic acid anhydride 
• 94594-90-8 (2R)-bornane-10,2-sultam 
• 167872-57-3 3-benzyloxy-2-bromopropanoyl bromide 
• 60886-80-8 (1S)-(-)-camphorsulfonylimine 
• 60886-80-8 (+/-)-8,8-dimethyl-4,5,6,7-tetrahydro-3ar,6c-methano-benz[c]isothiazole-2,2-dioxide 
• 21286-54-4 (+)-(1S)-Campher-10-sulfonsaeure-chlorid 
• 60933-63-3 (1S)-10-camphorsulfonamide 
• 21286-54-4 Camphorsulfonyl chloride 

Downstream Products

• 133706-01-1 ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-(3-phenyl-2-trimethylsilanyloxy-isoxazolidin-5-yl)-methanone 
• 145625-20-3 3-<(1S)-N-(tert-butyloxycarbonyl)amino-2-phenylethyl>-5-<(2R)-(bornane-10,2-sultamyl)-N-carbonyl>-(5R)-Δ²-isoxazoline 
• 145679-60-3 {(S)-1-[(S)-5-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-4,5-dihydro-isoxazol-3-yl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 145625-16-7 3-<(4R)-3-carboxybenzoxy-2,2-dimethyl-4-oxazolidinyl>-5-<(2R)-(bornane-10,2-sultamyl)-N-carbonyl>-(5R)-Δ²-isoxazoline 
• 267420-55-3 (3R,5R)-1-benzyl-5-(2-furyl)-3-hydroxypyrrolidin-2-one 
• 267420-56-4 (3R,5S)-1-benzyl-5-(2-furyl)-3-hydroxypyrrolidin-2-one 
• 446242-99-5 ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-((S)-1-phenyl-aziridin-2-yl)-methanone 
• 446242-98-4 ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-((R)-1-phenyl-aziridin-2-yl)-methanone 
• 446873-09-2 [(1R,2R,3S,4S)-7-Benzyl-3-(6-chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept-2-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone 
• 119897-84-6 ((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)((R)-3-phenyl-4,5-dihydroisoxazol-5-yl)methanone 

Relevant articles and documents

ASYMMETRISCHE INDUKTION BEI DER NI(0)-KATALYSIERTEN -CYCLOADDITION VON CAMPHERSULTAMACRYLAT MIT METHYLENCYCLOPROPANEN

The asymmetric Ni(0)-catalyzed cycloaddition of (-)-camphorsultamacrylate with methylenecyclopropane or 2,2-dimethylmethylenecyclopropane leads to 3-methylenecyclopentanecarboxylic amides in high optical yields up to 98percent de.

CONJUGATE OF CELL-BINDING RECEPTOR WITH CYTOTOXIC AGENT

PROBLEM TO BE SOLVED: To provide a conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule for targeted treatment. SOLUTION: According to the present invention, there is provided a conjugate having a structure of formula (I) and a pharmaceutical acceptable salt and a solvate thereof. The conjugate is used for treating cancer, autoimmune disease, and infectious disease. (T is a targeting or binding ligand; L is a releasable linker; a broken line is a linkage bond that L connects to a molecule inside the bracket independently; n is an integer of 1 to 20; m is an integer of 1 to 10; and a structure in parentheses is a potent antimitotic agent/drug.) SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Improved procedure for the synthesis of (2R)-N-propenoylbornane-2,10-sultam

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