N⁶-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine

Base Information

• Chemical Name: N⁶-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine
• CAS No.: 932740-13-1
• Molecular Formula: C₂₃H₂₉N₇O₆
• Molecular Weight: 499.527
• Mol file: 932740-13-1.mol

Synonyms:N⁶-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine

Chemical Property of N⁶-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine

There total 8 articles about N⁶-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N6-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-2',3'-isopropylidene-5'-oxo-5'-deoxyadenosine (932740-10-8) → N6-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine (932740-13-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h; Heating;

DOI:10.1021/jm061279i

Reference yield:

N-benzyloxycarbonyl-1,3-diaminopropane (46460-73-5) → N6-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine (932740-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / diisopropylethylamine / ethanol / 18 h / Heating

2: 63 percent / aq. HCl / dioxane / 1 h / Heating

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol;

DOI:10.1021/jm061279i

Reference yield:

2',3'-O-isopropylideneinosine (2140-11-6) → N6-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-5'-oxo-5'-deoxyadenosine (932740-13-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / 2,2,6,6-tetramethyl-1-piperidinyloxy free radical; iodosobenzene diacetate / acetonitrile; H₂O / 4 h / 20 °C

2: SOCl₂; DMF / CHCl₃ / 5 h / Heating

3: 941 mg / tetrahydrofuran / 0.5 h / 5 - 20 °C

4: 91 percent / diisopropylethylamine / ethanol / 18 h / Heating

5: 63 percent / aq. HCl / dioxane / 1 h / Heating

With hydrogenchloride; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; water; acetonitrile;

DOI:10.1021/jm061279i

upstream raw materials:

N⁶-(3-benzyloxycarbonylaminopropyl)-5'-ethylamino-2',3'-isopropylidene-5'-oxo-5'-deoxyadenosine

N-benzyloxycarbonyl-1,3-diaminopropane

2',3'-O-isopropylideneinosine

benzyl chloroformate