Technology Process of (E)-ethyl 5-phenyl-6-(quinolin-2-yl)hex-2-enoate
There total 3 articles about (E)-ethyl 5-phenyl-6-(quinolin-2-yl)hex-2-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethoxyphosphoryl-acetic acid ethyl ester;
With
1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride;
In
acetonitrile;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
C23H22N2O;
In
acetonitrile;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol200217y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: scandium tris(trifluoromethanesulfonate) / chlorobenzene / 72 h / 20 - 120 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.17 h / -78 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.17 h / 20 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
With
diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; scandium tris(trifluoromethanesulfonate);
In
hexane; dichloromethane; chlorobenzene; acetonitrile;
DOI:10.1021/ol200217y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: scandium tris(trifluoromethanesulfonate) / chlorobenzene / 72 h / 20 - 120 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.17 h / -78 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.17 h / 20 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
With
diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; scandium tris(trifluoromethanesulfonate);
In
hexane; dichloromethane; chlorobenzene; acetonitrile;
DOI:10.1021/ol200217y
