Celecoxib iMpurity-G

Base Information

Chemical Name:Celecoxib iMpurity-G
CAS No.:1061214-06-9
Molecular Formula:C₁₅H₁₇N₃O₂S
Molecular Weight:303.385
Hs Code.:2935904000

Synonyms:4-[2-[1-(4-methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide

Suppliers and Price of Celecoxib iMpurity-G

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[2-[1-(4-Methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide
100mg
$ 145.00

Ambeed
4-(2-(1-(p-Tolyl)ethylidene)hydrazinyl)benzenesulfonamide 97%
1g
$ 250.00

Ambeed
4-(2-(1-(p-Tolyl)ethylidene)hydrazinyl)benzenesulfonamide 97%
250mg
$ 94.00

Ambeed
4-(2-(1-(p-Tolyl)ethylidene)hydrazinyl)benzenesulfonamide 97%
100mg
$ 68.00

Total 14 raw suppliers

Chemical Property of Celecoxib iMpurity-G

Chemical Property:

Melting Point:224-226 °C(Solv: ethanol (64-17-5))
Boiling Point:484.9±55.0 °C(Predicted)
PKA:10.53±0.12(Predicted)
Density:1.25±0.1 g/cm3(Predicted)
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-[2-[1-(4-Methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-[2-[1-(4-Methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide is an impurity of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

Technology Process of Celecoxib iMpurity-G

There total 2 articles about Celecoxib iMpurity-G which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 122-00-9
para-methylacetophenone

: 1061214-06-9
4-[2-[1-(4-methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide

Guidance literature:: With sodium acetate; In methanol; water; for 1h; Reflux;
DOI:10.1002/adsc.201501130

Reference yield:

: 122-00-9
para-methylacetophenone

: 4392-54-5
4-aminosulfonylphenylhydrazine

: 1061214-06-9
4-[2-[1-(4-methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide

Guidance literature:: With acetic acid; In ethanol; water; for 0.5h; Reflux;
DOI:10.1016/j.bmc.2016.04.061

Reference yield: 98.0%

: 1061214-06-9
4-[2-[1-(4-methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1448798-93-3
N-[(dimethylamino)methylidene]-4-{2-[1-(4-methylphenyl)ethylidene]hydrazino}benzenesulfonamide

Guidance literature:: In neat (no solvent); at 20 ℃; for 0.25h; under 760.051 Torr; chemoselective reaction; Green chemistry;
DOI:10.1039/c3gc40797g