(2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine

Base Information

Chemical Name:(2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine
CAS No.:146097-56-5
Molecular Formula:C₁₆H₂₄N₂O₃S
Molecular Weight:324.444
Hs Code.:

Synonyms:(2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine

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Technology Process of (2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine

There total 2 articles about (2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2644-99-7
2-(N-methyl-N-(p-toluenesulfonamido))acetic acid

: 146097-56-5
(2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 1,2-dichloro-ethane / 2 h / Heating

2: 10.9 g / aq. NaOH / CH₂Cl₂

With sodium hydroxide; thionyl chloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/1521-3765(20020802)8:15<3411::AID-CHEM3411>3.0.CO;2-A

Reference yield:

: 95631-21-3
N-methyl-N-tosylglycinoyl chloride

: 70144-18-2
(2R,5R)-2,5-dimethyltetrahydro-1H-1-pyrrolylidium chloride

: 146097-56-5
(2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine

Guidance literature:: With sodium hydroxide; In dichloromethane;
DOI:10.1002/1521-3765(20020802)8:15<3411::AID-CHEM3411>3.0.CO;2-A

Reference yield: 71.0%

: 590-18-1
(Z)-2-Butene

: 146097-56-5
(2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine

: 146097-49-6
(2S,3R,4R)-3,4-dimethyl-(N-methyl-N-tosylamino)cyclobutanone

Guidance literature:: (Z)-2-Butene; (2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine; With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; In 1,2-dichloro-ethane; at 20 ℃; for 3h;

With water; In tetrachloromethane; at 20 ℃; for 12h;
DOI:10.1002/1521-3765(20020802)8:15<3411::AID-CHEM3411>3.0.CO;2-A