(2R,5R)-2,5-dimethylpyrrolidine hydrochloride

Base Information

• Chemical Name: (2R,5R)-2,5-dimethylpyrrolidine hydrochloride
• CAS No.: 70144-18-2
• Molecular Formula: C6H14ClN
• Molecular Weight: 135.64
• European Community (EC) Number: 891-214-0,970-099-1
• DSSTox Substance ID: DTXSID70483245
• Mol file: 70144-18-2.mol

Synonyms:70144-18-2;(2R,5R)-2,5-dimethylpyrrolidine hydrochloride;(2R,5R)-2,5-Dimethyl-pyrrolidine hydrochloride;(2R,5R)-2,5-Dimethylpyrrolidine HCl;(2R,5R)-2,5-dimethylpyrrolidine;hydrochloride;MFCD00269980;114143-75-8;(-)-(2R,5R)-2,5-Dimethylpyrrolidine, Hydrochloride, 90% (contains meso-isomer);trans-2,5-Dimethylpyrrolidine hydrochloride;(-)-(2R,5R)-2,5-DIMETHYLPYRROLIDINE, HYDROCHLORIDE;(2S,5S)-rel-2,5-dimethylpyrrolidine hydrochloride;rel-(2R,5R)-2,5-Dimethylpyrrolidine hydrochloride;SCHEMBL489345;DTXSID70483245;AFHNFHHYTYQLIO-KGZKBUQUSA-N;(trans)-2,5-dimethylpyrrolidine hcl;AKOS025147230;AMY202003238;AS-54353;(2R,5R)-2,5-Dimethylpyrrolidinium chloride;CS-0053461;P17787;rac trans-2,5-Dimethylpyrrolidine hydrochloride;(-)-(2R,5R)-2,5-Dimethylpyrrolidine,hydrochloride;(2R,5R)-2,5-Dimethylpyrrolidine--hydrogen chloride (1/1);(-)-(2R,5R)-2,5-Dimethylpyrrolidine, Hydrochloride, 90per cent (contains meso-isomer)

Chemical Property of (2R,5R)-2,5-dimethylpyrrolidine hydrochloride

Chemical Property:

• Melting Point: 196-198°C
• PSA: 12.03000
• LogP: 2.27760
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 135.0814771
• Heavy Atom Count: 8
• Complexity: 53.2

Purity/Quality:

NLT 98% ^*data from raw suppliers

(-)-(2R,5R)-2,5-Dimethylpyrrolidine,Hydrochloride,90%(containsmeso-isomer) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCC(N1)C.Cl
• Isomeric SMILES: C[C@@H]1CC[C@H](N1)C.Cl
• Uses: (-)-(2R,5R)-2,5-DIMETHYLPYRROLIDINE, HYDROCHLORIDE is used for asymmetric syntheses Reagent used for asymmetric syntheses.

Technology Process of (2R,5R)-2,5-dimethylpyrrolidine hydrochloride

There total 16 articles about (2R,5R)-2,5-dimethylpyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-aminohex-5-ene (7380-76-9,73604-43-0) → trans-2,5-Dimethylpyrrolidine Hydrochloride (4209-65-8,4832-49-9,63639-02-1,70144-18-2,114143-75-8,138133-34-3)

Guidance literature:

2-aminohex-5-ene; With 1,3-bis(2-iPrC₆H₄)-2-bis(TMS)N-2,1,3-scandiadiazolidine; In benzene; at 60 ℃; for 3h;

With hydrogenchloride; In diethyl ether; benzene; at -15 ℃;

DOI:10.1021/ol051574h

Reference yield: 90.0%

(-)-N-benzyl-(2R,5R)-2,5-dimethylpyrrolidine (119008-53-6) → (2R,5R)-2,5-dimethyltetrahydro-1H-1-pyrrolylidium chloride (70144-18-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 18h; under 5171.48 Torr;

DOI:10.1071/CH03238

Reference yield: 90.0%

(2R,5R)-2,5-Dimethyl-pyrrolidine-1-carboxylic acid benzyl ester (113774-92-8) → (2R,5R)-2,5-dimethyltetrahydro-1H-1-pyrrolylidium chloride (70144-18-2)

Guidance literature:

With hydrogenchloride; chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)96049-0

upstream raw materials:

trans-N-(Carbobenzyloxy)-2,5-dimethylpyrrolidine

2-aminohex-5-ene

hex-5-en-2-one oxime

(E)-hex-5-en-2-one oxime

Downstream raw materials:

2,5-dimethyl-1-(phenylethynyl)-pyrrolidine

(2R,5R)-2,5-dimethylpyrrolidine N-carbohydroxamic acid

(2R,5R)-2,5-dimethylpyrrolidine (R)-MTPA amide

(2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine

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