(3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne

Base Information

Chemical Name:(3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne
CAS No.:1300116-86-2
Molecular Formula:C₂₈H₃₁BrO₃Si
Molecular Weight:523.542
Hs Code.:

Synonyms:(3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne

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Chemical Property of (3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne

Chemical Property:

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Technology Process of (3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne

There total 4 articles about (3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₂O₃Si

: 1300116-86-2
(3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne

Guidance literature:: With N-Bromosuccinimide; silver nitrate; In acetone;
DOI:10.1016/j.tetlet.2008.03.023

Reference yield:

: 118620-86-3,132437-17-3
(2S,3S)-4-(p-methoxybenzyloxy)-2,3-(isopropylidenedioxy)-butan-1-ol

: 1300116-86-2
(3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne

Guidance literature:: Multi-step reaction with 4 steps

1: tetrachloromethane; triphenylphosphine / 30 h / Reflux

2: n-butyllithium; isopropylamine / tetrahydrofuran; hexane / 3 h / -78 - 0 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4: N-Bromosuccinimide; silver nitrate / acetone / 12 h / 20 °C / Darkness

With 1H-imidazole; tetrachloromethane; N-Bromosuccinimide; n-butyllithium; silver nitrate; isopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone;
DOI:10.1002/chem.201003265

Reference yield:

: 118620-85-2
(2R)-1-(4-methoxybenzyloxy)but-3-yn-2-ol

: 1300116-86-2
(3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2: N-Bromosuccinimide; silver nitrate / acetone / 12 h / 20 °C / Darkness

With 1H-imidazole; N-Bromosuccinimide; silver nitrate; In N,N-dimethyl-formamide; acetone;
DOI:10.1002/chem.201003265