118620-85-2

Upstream product

• 1429480-77-2 1-(4-methoxybenzyloxy)but-3-yn-2-yl acetate 
• 1429480-76-1 1-(4-methoxybenzyloxy)-4-(trimethylsilyl)but-3-yn-2-ol 
• 121289-23-4 p-methoxybenzyloxyacetaldehyde 
• 118620-86-3 (2S,3S)-4-(p-methoxybenzyloxy)-2,3-(isopropylidenedioxy)-butan-1-ol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 118620-84-1 (4R,5S)-[(4-methoxybenzyloxy)methyl]-5-chloromethyl-2,2-dimethyl-1,3-dioxolane 

Downstream Products

• 118620-90-9 (R)-4-Ethynyl-2-(4-methoxy-phenyl)-[1,3]dioxolane 
• 1005345-93-6 CHOCH₂CH₂CH(OSiC₆H₁₅)CH₂OCH₂C₆H₄OCH₃ 
• 1300117-60-5 (1S,2R)-(E)-2-(N-benzyl-4-methylbenzenesulfonylamino)-5-(4-methoxybenzyloxy)-1-(trimethylsilyl)pent-3-enyl (R)-2-methoxy-2-phenylacetate 
• 1300117-59-2 (1S,2R)-(E)-2-(N-benzyl-4-methylbenzenesulfonylamino)-5-(4-methoxybenzyloxy)-1-(trimethylsilyl)pent-3-enyl (S)-2-methoxy-2-phenylacetate 
• 1029537-52-7 N-benzyl-N-{(1R,2R)-2-hydroxy-3-oxo-1-[(E)-3-(4-methoxybenzyloxy)prop-1-ene]butyl}-4-methylbenzenesulfonamide 
• 1029537-49-2 N-benzyl-N-[(E)-(R)-1-((S)-1-hydroxy-3-trimethylsilylprop-2-ynyl)-4-(4-methoxybenzyloxy)but-2-enyl]-4-methylbenzenesulfonamide 
• 1029537-47-0 N-benzyl-N-{(3R)-(E)-3-(prop-2-ynyl)oxy-4-[(4-methoxybenzyl)oxy]but-1-enyl}-4-methylbenzenesulfonamide 
• 1029537-45-8 N-benzyl-N-[(E)-(3S)-3-hydroxy-4-(4-methoxybenzyloxy)but-1-enyl]-4-methylbenzenesulfonamide 
• 1300116-94-2 N-benzyl-N-[(3S)-3-hydroxy-4-(4-methoxybenzyloxy)but-1-ynyl]-4-methylbenzenesulfonamide 
• 1300116-90-8 N-benzyl-N-{(3S)-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-ynyl}-4-methylbenzenesulfonamide 
• 1300116-86-2 (3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-4-(4-methoxybenzyloxy)but-1-yne 
• 118620-97-6 4-Methoxy-benzoic acid 2-hydroxy-but-3-ynyl ester 
• 118620-98-7 4-Methoxy-benzoic acid 1-hydroxymethyl-prop-2-ynyl ester 

Relevant academic research and scientific papers

Total synthesis of (-)-cinatrin C1 based on an In(OTf) 3-catalyzed Conia-ene reaction

The stereocontrolled total synthesis of (-)-cinatrin C1, a phospholipase A2 inhibitor, has been accomplished. The key feature includes the stereoselective construction of the highly substituted tetrahydrofuran core by In(OTf)3-catalyzed Conia-ene reaction of the oxygen-tethered acetylenic malonic ester followed by dihydroxylation with concomitant lactonization.

Synthesis of 1,2-amino alcohols by sigmatropic rearrangements of 3-(N-Tosylamino)allylic alcohol derivatives

Sigmatropic rearrangements of 3-(N-tosylamino)allylic alcohol derivatives, a particular subclass of functionalized enamides, have been investigated. Whereas the presence of the nitrogen atom alters the stereochemical outcome of Ireland-Claisen rearrangeme

AN EXPEDITIOUS APPROACH FOR THE SYNTHESIS OF OPTICALLY ACTIVE ACETYLENIC ALCOHOLS

A practical method for the synthesis of acetylenic alcohols by base induced elimination of β-alkoxy chlorides is described.