ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]

Base Information

• Chemical Name: ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]
• CAS No.: 245469-59-4
• Molecular Formula: C₁₇H₁₆ClIO₃S
• Molecular Weight: 462.736
• Mol file: 245469-59-4.mol

Synonyms:ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]

Chemical Property of ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]

There total 3 articles about ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

p-Chlorothiophenol (106-54-7) + ethanone-1-[3-methoxy-4-(2-bromoethoxy)-5-iodophenyl] (245469-58-3) → ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl] (245469-59-4)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1016/S0040-4020(99)00544-X

Reference yield:

1-(4-hydroxy-3-iodo-5-methoxy-phenyl)ethan-1-one (103440-59-1) → ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl] (245469-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / K₂CO₃ / dimethylformamide / 3.5 h / 78 °C

2: 86.2 percent / NaOMe / tetrahydrofuran / 8 h / 20 °C

With sodium methylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl] (245469-59-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / NaOH; I₂ / H₂O / 3.5 h / Heating

2: 50 percent / K₂CO₃ / dimethylformamide / 3.5 h / 78 °C

3: 86.2 percent / NaOMe / tetrahydrofuran / 8 h / 20 °C

With sodium hydroxide; iodine; sodium methylate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

upstream raw materials:

p-Chlorothiophenol

ethanone-1-[3-methoxy-4-(2-bromoethoxy)-5-iodophenyl]

1-(4-hydroxy-3-iodo-5-methoxy-phenyl)ethan-1-one

1-(3-methoxy-4-hydroxyphenyl)ethanone

Downstream raw materials:

1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

(+/-)-cis-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran

2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran