(1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N²-isobutyrylguanine

Base Information

• Chemical Name: (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N²-isobutyrylguanine
• CAS No.: 283598-03-8
• Molecular Formula: C₂₂H₂₅N₅O₅
• Molecular Weight: 439.471

Synonyms:(1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N²-isobutyrylguanine

Chemical Property of (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N²-isobutyrylguanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N²-isobutyrylguanine

There total 3 articles about (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N²-isobutyrylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N2-isobutylguanine (283597-99-9) → (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N2-isobutyrylguanine (283598-03-8)

Guidance literature:

With Lipase MY; In phosphate buffer; acetone; at 36 ℃; for 192h; pH=7.0; Enzymatic reaction;

DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

<1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester (132294-18-9) → (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N2-isobutyrylguanine (283598-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethylformamide / 10 h / 100 °C

1.2: TFA / H₂O / 12 h / 20 °C

1.3: 32 percent / Py / 0.5 h / 0 °C

2.1: 75 percent / lipase MY / acetone; aq. phosphate buffer / 192 h / 36 °C / pH 7.0 / Enzymatic reaction

With Lipase MY; In phosphate buffer; N,N-dimethyl-formamide; acetone; 1.1: Substitution / 1.2: Hydrolysis / 1.3: Acylation / 2.1: Hydrolysis;

DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

2-Amino-6-chloropurin (10310-21-1) → (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N2-isobutyrylguanine (283598-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethylformamide / 10 h / 100 °C

1.2: TFA / H₂O / 12 h / 20 °C

1.3: 32 percent / Py / 0.5 h / 0 °C

2.1: 75 percent / lipase MY / acetone; aq. phosphate buffer / 192 h / 36 °C / pH 7.0 / Enzymatic reaction

With Lipase MY; In phosphate buffer; N,N-dimethyl-formamide; acetone; 1.1: Substitution / 1.2: Hydrolysis / 1.3: Acylation / 2.1: Hydrolysis;

DOI:10.1016/S0040-4020(00)00162-9

upstream raw materials:

(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine

<1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

2-Amino-6-chloropurin

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 283598-03-8 (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N²-isobutyrylguanine

Send

Send

Metric Ton KG G Pound L ML

Send

Send