2,3,5-trimethoxyphenylacetylene

Base Information

Chemical Name:2,3,5-trimethoxyphenylacetylene
CAS No.:1321913-91-0
Molecular Formula:C₁₁H₁₂O₃
Molecular Weight:192.214
Hs Code.:

Synonyms:2,3,5-trimethoxyphenylacetylene

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Chemical Property of 2,3,5-trimethoxyphenylacetylene

Chemical Property:

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Technology Process of 2,3,5-trimethoxyphenylacetylene

There total 4 articles about 2,3,5-trimethoxyphenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1321914-21-9
(2,3,5-trimethoxyphenylethynyl)trimethylsilane

: 1321913-91-0
2,3,5-trimethoxyphenylacetylene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.05.030

Reference yield:

: 2973-76-4
5-bromo-4-hydroxy-3-methoxybenzaldehyde

: 1321913-91-0
2,3,5-trimethoxyphenylacetylene

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; potassium hydroxide / water / 0.5 h / 40 °C

1.2: 20 °C

2.1: potassium carbonate / acetone / 14 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine / 1,4-dioxane / 20 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium carbonate; diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; acetone; 1.1: Dakin reaction / 3.1: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.030

Reference yield:

: 61654-67-9
2,5-dihydroxy-3-methoxy-1-bromobenzene

: 1321913-91-0
2,3,5-trimethoxyphenylacetylene

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 14 h / 20 °C / Inert atmosphere

2: copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine / 1,4-dioxane / 20 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; potassium carbonate; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; acetone; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.030