8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid

Base Information

Chemical Name:8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid
CAS No.:1532540-03-6
Molecular Formula:C₂₉H₃₃N₇O₅
Molecular Weight:559.625
Hs Code.:

Synonyms:8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid

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Chemical Property of 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid

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Technology Process of 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid

There total 6 articles about 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1532540-02-5
methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate

: 1532540-03-6
8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid

Guidance literature:: With sodium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;
DOI:10.1021/ic402234k

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 1532540-03-6
8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / 4 - 20 °C

2.1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: methylamine / ethanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

4.2: 3 h / 20 °C / Inert atmosphere

5.1: sodium hydroxide / N,N-dimethyl-formamide; water / 0.33 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; methylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ic402234k

Reference yield:

: 1215876-48-4
N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-4-((2,2,2-trifluoroacetamido)methyl)benzamide

: 1532540-03-6
8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: methylamine / ethanol / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / N,N-dimethyl-formamide; water / 0.33 h / 20 °C

With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; methylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ic402234k