methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate

Base Information

Chemical Name:methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate
CAS No.:1532540-02-5
Molecular Formula:C₃₀H₃₅N₇O₅
Molecular Weight:573.652
Hs Code.:

Synonyms:methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate

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Chemical Property of methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate

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Technology Process of methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate

There total 4 articles about methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1609637-03-7
C₁₃H₁₉NO₆

: 1215876-49-5
N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-4-(aminomethyl)benzamide

: 1532540-02-5
methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate

Guidance literature:: C₁₃H₁₉NO₆; With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-4-(aminomethyl)benzamide; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ic402234k

Reference yield:

: 1215876-48-4
N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-4-((2,2,2-trifluoroacetamido)methyl)benzamide

: 1532540-02-5
methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methylamine / ethanol / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; methylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ic402234k

Reference yield:

: 130029-61-7
4-[[(2,2,2-trifluoroacetyl)amino]methyl]benzoic acid

: 1532540-02-5
methyl 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: methylamine / ethanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

With 1-hydroxy-pyrrolidine-2,5-dione; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; methylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ic402234k