[2-(4-Chlorophenoxy)phenyl]methanol

Base Information

• Chemical Name: [2-(4-Chlorophenoxy)phenyl]methanol
• CAS No.: 25562-90-7
• Molecular Formula: C₁₃H₁₁ClO₂
• Molecular Weight: 234.682
• DSSTox Substance ID: DTXSID301297728
• Mol file: 25562-90-7.mol

Synonyms:[2-(4-chlorophenoxy)phenyl]methanol;25562-90-7;Oprea1_649783;DTXSID301297728;2-(4-Chlorophenoxy)benzenemethanol;MFCD02081998;AKOS005085931;2P-036

Chemical Property of [2-(4-Chlorophenoxy)phenyl]methanol

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 234.0447573
• Heavy Atom Count: 16
• Complexity: 202

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CO)OC2=CC=C(C=C2)Cl

Technology Process of [2-(4-Chlorophenoxy)phenyl]methanol

There total 5 articles about [2-(4-Chlorophenoxy)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(4-chlorophenoxy)benzaldehyde (111826-11-0) → 2-<4-Chlorphenyloxy>-benzylalkohol (25562-90-7)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; silver(I) hexafluorophosphate; tripropylsilane; N-ethyl-N,N-diisopropylamine; In water; at 100 ℃; for 24h;

DOI:10.1055/s-0033-1339660

Reference yield:

2-(4-chloro-phenoxy)-benzoic acid (6410-65-7) → 2-<4-Chlorphenyloxy>-benzylalkohol (25562-90-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → 2-<4-Chlorphenyloxy>-benzylalkohol (25562-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) K₂CO₃, PhNO₂, (ii) /BRN= 507004/

2: LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; In diethyl ether;

upstream raw materials:

2-(4-chloro-phenoxy)-benzoic acid

4-chloro-phenol

2-Fluorobenzaldehyde

2-(4-chlorophenoxy)benzaldehyde

Downstream raw materials:

C₁₄H₁₃ClN₂OS

2-(4-chlorophenoxy)benzaldehyde

o-(p-chlorophenoxy)phenylacetic acid

2-(4-chlorophenoxy)phenylacetonitrile