1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone

Base Information

• Chemical Name: 1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone
• CAS No.: 709036-66-8
• Molecular Formula: C₁₇H₁₁Cl₃N₂O
• Molecular Weight: 365.646
• Mol file: 709036-66-8.mol

Synonyms:1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone

Chemical Property of 1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone

There total 6 articles about 1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-aniline (106-47-8) → 1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone (709036-66-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trimethylaluminum / toluene / 4.67 h / 0 - 20 °C

1.2: 85 °C

2.1: sodium hydrogencarbonate / isopropyl alcohol / 85 °C

3.1: toluene-4-sulfonic acid / toluene / Heating / reflux

4.1: lithium hydroxide; water / methanol / 1 h / Heating / reflux

5.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / tetrahydrofuran; ethyl acetate / 20 °C

6.1: tetrahydrofuran; diethyl ether / 1 h / 0 °C

With lithium hydroxide; water; trimethylaluminum; sodium hydrogencarbonate; toluene-4-sulfonic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-1H-imidazole-4-carboxylic acid (505074-55-5) → 1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone (709036-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / tetrahydrofuran; ethyl acetate / 20 °C

2: tetrahydrofuran; diethyl ether / 1 h / 0 °C

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; diethyl ether; ethyl acetate;

Reference yield:

benzonitrile (100-47-0) → 1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone (709036-66-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trimethylaluminum / toluene / 4.67 h / 0 - 20 °C

1.2: 85 °C

2.1: sodium hydrogencarbonate / isopropyl alcohol / 85 °C

3.1: toluene-4-sulfonic acid / toluene / Heating / reflux

4.1: lithium hydroxide; water / methanol / 1 h / Heating / reflux

5.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / tetrahydrofuran; ethyl acetate / 20 °C

6.1: tetrahydrofuran; diethyl ether / 1 h / 0 °C

With lithium hydroxide; water; trimethylaluminum; sodium hydrogencarbonate; toluene-4-sulfonic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; isopropyl alcohol; toluene;

upstream raw materials:

1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-4-hydroxy-4,5-dihydro-1H-imidazole-4-carboxylic Acid Ethyl Ester

4-chloro-aniline

benzonitrile

2,4-dichloro-N-(4-chlorophenyl)benzenecarboximidamide

Downstream raw materials:

2-Bromo-1-[1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone

1-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-2-morpholin-4-yl-ethanone