benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate

Base Information

Chemical Name:benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate
CAS No.:1195778-49-4
Molecular Formula:C₂₅H₂₂N₄O₄
Molecular Weight:442.474
Hs Code.:

Synonyms:benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate

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Chemical Property of benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate

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Technology Process of benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate

There total 7 articles about benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1195781-13-5
benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}carbamate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1195778-49-4
benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate

Guidance literature:: benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}carbamate; cyclopropanecarboxylic acid chloride; In ISOPROPYLAMIDE; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In ISOPROPYLAMIDE; water;

Reference yield:

: 1195781-05-5
benzyl {4-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

: 1195778-49-4
benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; iron; calcium chloride / ethanol / 16 h / Reflux

2.1: pyridine / 16 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: trifluoroacetic anhydride / tetrahydrofuran / 48 h / 20 °C

4.3: 10 h / 45 °C

5.1: ISOPROPYLAMIDE / 1 h / 20 °C

With pyridine; water; iron; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; calcium chloride; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 1195781-09-9
benzyl {4-[(6-{[(4-methylphenyl)sulfonyl]amino}pyridin-3-yl)oxy]phenyl}carbamate

: 1195778-49-4
benzyl [4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: trifluoroacetic anhydride / tetrahydrofuran / 48 h / 20 °C

2.3: 10 h / 45 °C

3.1: ISOPROPYLAMIDE / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; ISOPROPYLAMIDE; N,N-dimethyl-formamide;