cis/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Base Information

Chemical Name:cis/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester
CAS No.:1417611-64-3
Molecular Formula:C₂₄H₃₃NO₆
Molecular Weight:431.529
Hs Code.:

Synonyms:cis/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

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Chemical Property of cis/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

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Technology Process of cis/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

There total 2 articles about cis/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417611-61-0
3-(3,4,5-trimethoxyphenyl)propiolic acid 4-oxocyclohexyl ester

: 6850-65-3,27489-62-9,40525-78-8
cis-4-aminocyclohexanol

: 1417611-64-3
cis/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

: 1417611-65-4
trans/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Guidance literature:: 3-(3,4,5-trimethoxyphenyl)propiolic acid 4-oxocyclohexyl ester; cis-4-aminocyclohexanol; With titanium(IV) isopropylate; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In ethanol; for 20h;
DOI:10.1016/j.bmc.2012.11.019

Reference yield:

: 13482-22-9
4-hydroxycyclohexanone

: 1417611-64-3
cis/cis-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

2.1: titanium(IV) isopropylate / 3 h / 20 °C

2.2: 20 h

With titanium(IV) isopropylate; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmc.2012.11.019