4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
• CAS No.: 1235395-65-9
• Molecular Formula: C₁₉H₁₃ClN₆O₃S₂
• Molecular Weight: 472.936

Synonyms:4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Chemical Property of 4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

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Technology Process of 4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

There total 4 articles about 4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (1235406-40-2) + 4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenol (36141-23-8) → 4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (1235395-65-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1021/acs.jmedchem.7b00598

Reference yield:

6-chloro-4H-chromen-4-one (33533-99-2) → 4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (1235395-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / 18 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

With potassium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00598

Reference yield:

3-cyano-4-fluorobenzene-1-sulfonyl chloride (351003-23-1) → 4-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (1235395-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 1 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

With potassium carbonate; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00598

upstream raw materials:

6-chloro-4H-chromen-4-one

3-cyano-4-fluorobenzene-1-sulfonyl chloride

3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenol

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