Erdosteine

Base Information

Chemical Name:Erdosteine
CAS No.:84611-23-4
Molecular Formula:C8H11NO4S2
Molecular Weight:249.312
Hs Code.:2934999090
European Community (EC) Number:642-172-5
UNII:76J0853EKA
DSSTox Substance ID:DTXSID8048735
Nikkaji Number:J325.880G
Wikipedia:Erdosteine
Wikidata:Q3731252
NCI Thesaurus Code:C61750
Metabolomics Workbench ID:149386
ChEMBL ID:CHEMBL1697744
Mol file:84611-23-4.mol

Synonyms:(+-)-((((tetrahydro-2-oxo-3-thienyl)carbamoyl)methyl)thio)acetic acid;Dostein;Edirel;erdosteine;Esteclin;RV 144;RV-144;S-(2-(N-3-(2-oxo-tetrahydrothienyl)acetamido))thioglycolic acid;Vectrine

Suppliers and Price of Erdosteine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Erdosteine
2g
$ 215.00

TCI Chemical
Erdosteine >98.0%(GC)(T)
1g
$ 36.00

TCI Chemical
Erdosteine >98.0%(GC)(T)
5g
$ 108.00

DC Chemicals
Erdosteine >99%
250 mg
$ 500.00

Crysdot
Erdosteine 98+%
1g
$ 141.00

ChemScene
Erdosteine 99.83%
500mg
$ 80.00

ChemScene
Erdosteine 99.83%
1g
$ 132.00

ChemScene
Erdosteine 99.83%
5g
$ 528.00

Chem-Impex
Erdosteine,98%(Assaybytitration,GC) 98%(Assaybytitration,GC)
5G
$ 502.88

Chem-Impex
Erdosteine,98%(Assaybytitration,GC) 98%(Assaybytitration,GC)
1G
$ 132.16

Total 146 raw suppliers

Chemical Property of Erdosteine

Chemical Property:

Appearance/Colour:white or almost white crystalline powder
Vapor Pressure:1.82E-15mmHg at 25°C
Melting Point:156-160 °C
Refractive Index:1.615
Boiling Point:590.4 °C at 760 mmHg
PKA:3.71(at 25℃)
Flash Point:310.8 °C
PSA：134.07000
Density:1.48 g/cm³
LogP:0.34340
Storage Temp.:Refrigerator
Solubility.:Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:249.01295018
Heavy Atom Count:15
Complexity:282

Purity/Quality:

99% ^*data from raw suppliers

Erdosteine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CSC(=O)C1NC(=O)CSCC(=O)O
Recent ClinicalTrials:Erdosteine (Erdotin) Versus Standard Care Plus Placebo on Erdosteine for Treatment of Cough in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
Recent EU Clinical Trials:The efficacy and safety of erdosteine in the long-term therapy of chronic obstructive pulmonary disease (COPD). A 12-month, randomised, double-blind, placebo-controlled, parallel group, multicenter study.
Description Erdosteine is a new expectorant introduced in France for the treatment of chronic bronchitis. Erdosteine possesses mucomodulator, mucolytic, mucokinetic and free radical scavenging properties. Its therapeutic efficacy has been demonstrated in patients affected by congestion and viscous mucus in higher and lower respiratory tracts as in acute and chronic bronchitis, sinusitis, otitis, tracheopharyngitis and coryza. Erdosteine acts through its active metabolites containing free sulfhydryl groups which are able to depolymerize the mucopolysaccharides of the excreatum by breaking the disulfide linkages (thereby lowing its viscosity). The prodrug approach provides unique characteristics to erdosteine by offering stable therapeutic efficacy and prevention of the gastric mucus from lythic phenomena. The agent was also reported to have local antiinflammatory and antielastase properties and enhances penetration of antibiotics into bronchial mucus. Erdosteine is a mucolytic agent and an antioxidant. It inhibits LPS-induced IκB kinase (IKK) activity, NF-κB-mediated transcription, and production of IL-6 and IL-1β in RAW 264.7 cells. Erdosteine (7.5 mg/kg) prevents depletion of renal catalase and glutathione peroxidase (GPX) and increases in renal malondialdehyde (MDA) and nitric oxide (NO) levels in a rat model of nephrotoxicity induced by cisplatin . It reduces spinal cord lipid peroxidation and destruction of spinal motor neurons in a rabbit model of spinal cord ischemia and reperfusion injury induced by thoracoabdominal aortic clamping. Erdosteine (150 mg/kg) reduces lung weight, MDA and protein carbonyl levels, and macrophage and neutrophil accumulation in a mouse model of acute lung injury induced by oleic acid (Item Nos. 90260 | 24659). Formulations containing erdosteine have been used in the treatment of chronic obstructive pulmonary disease (COPD).
Uses A mucolytic, developed for the treatment of chronic obstructive bronchitis. Erdosteine is a mucolytic. Erdosteine was developed for the treatment of chronic obstructive bronchitis.

Technology Process of Erdosteine

There total 2 articles about Erdosteine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%