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Homocysteine thiolactone is a reactive intermediate of homocysteine, an amino acid derived from the metabolism of methionine. It is a cyclic thioester compound that has been found to be toxic to cells and tissues in high concentrations. HOMOCYSTEINE THIOLACTONE is known for its potential to cause protein damage and modification, leading to a variety of adverse effects on cellular function. Its involvement in the development of cardiovascular disease, neurodegenerative disorders, and other pathological conditions has been noted. Furthermore, homocysteine thiolactone has been shown to induce oxidative stress and inflammation, which contribute to the progression of various diseases. The understanding and mitigation of the effects of homocysteine thiolactone on cellular function and health remain a significant area of research in the fields of biochemistry and medicine.

10593-85-8

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10593-85-8 Usage

Uses

Given the provided materials, there are no direct applications listed for homocysteine thiolactone. However, its role in research and medicine can be inferred as follows:
Used in Research and Medicine:
Homocysteine thiolactone is utilized as a subject of study for understanding its impact on cellular function and its involvement in the development of various diseases. The research aims to explore its toxic effects, its role in protein damage and modification, and its contribution to oxidative stress and inflammation. This knowledge is crucial for developing potential therapeutic strategies to mitigate its adverse effects on health.

Check Digit Verification of cas no

The CAS Registry Mumber 10593-85-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,9 and 3 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10593-85:
(7*1)+(6*0)+(5*5)+(4*9)+(3*3)+(2*8)+(1*5)=98
98 % 10 = 8
So 10593-85-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NOS/c5-3-1-2-7-4(3)6/h3H,1-2,5H2

10593-85-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name HOMOCYSTEINE THIOLACTONE

1.2 Other means of identification

Product number -
Other names DL-histidine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10593-85-8 SDS

10593-85-8Related news

N-Acetylcysteine supplementation decreased brain lipid and protein oxidations produced by experimental HOMOCYSTEINE THIOLACTONE (cas 10593-85-8) exposure: Relevance to neurodegeneration08/15/2019

High levels of homocysteine (Hcy) have neurotoxic effects. Homocysteine thiolactone (HcyT), a thioester of Hcy, plays a role in Hcy-induced toxicity. In this study, effects of HcyT treatment (500 mg/kg body weight/day in drinking water) for 6 weeks on serum Hcy levels and brain prooxidant-antiox...detailed

Application of GC–MS technique for the determination of HOMOCYSTEINE THIOLACTONE (cas 10593-85-8) in human urine08/14/2019

It is well established that homocysteine thiolactone (HTL) is associated with some health disorders, including cardiovascular diseases. HTL is a by-product of sulfur metabolic cycle. So far, its presence has been confirmed in human plasma and urine. It has been also shown that a vast majority of...detailed

10593-85-8Relevant academic research and scientific papers

Immonological detection of the homocystamide adduct and a thiolactone immunoassay for endogeneous homocysteine

-

, (2008/06/13)

An antibody specific for homocystamide adducts is disclosed. In a preferred embodiment of the present invention, the antibody is used to evaluate the level of homocysteine in a biological sample.

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