4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid

Base Information

Chemical Name:4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid
CAS No.:1428481-06-4
Molecular Formula:C₃₀H₂₉Cl₂N₃O₃S
Molecular Weight:582.551
Hs Code.:

Synonyms:4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid

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Chemical Property of 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid

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Technology Process of 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid

There total 8 articles about 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428482-22-7
C₃₁H₃₁Cl₂N₃O₃S

: 1428481-06-4
4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 - 60 ℃; for 57h; Sealed tube;

Reference yield:

: 1428482-14-7
2-bromo-5-thiocarbamoyl-benzoic acid methyl ester

: 1428481-06-4
4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 70 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 95 - 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

5: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 57 h / 20 - 60 °C / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1428482-17-0
4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2,4'-dicarboxylic acid 2-methyl ester

: 1428481-06-4
4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

2: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 57 h / 20 - 60 °C / Sealed tube

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;