5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine
CAS No.:209163-81-5
Molecular Formula:C₃₄H₃₃N₃O₉
Molecular Weight:627.651
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 209163-82-6
5-carboxymethyl-5'-O-dimethoxytrityl-2'-deoxyuridine

: 590-17-0
cyanomethyl bromide

: 209163-81-5
5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine

Guidance literature:: With potassium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 6h; Ambient temperature;
DOI:10.1016/S0040-4039(98)00660-1

Reference yield:

: 159555-13-2
3',5'-di-O-acetyl-5-(methoxycarbonylmethyl)-2'-deoxyuridine

: 209163-81-5
5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / sodium methoxide / methanol / 1 h / Ambient temperature

2: 91 percent

3: 1.0 N lithium hydroxide / tetrahydrofuran / 1 h / Ambient temperature

4: 70 percent / potassium carbonate / hexamethylphosphoric acid triamide / 6 h / Ambient temperature

With lithium hydroxide; sodium methylate; potassium carbonate; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4039(98)00660-1

Reference yield:

: 77181-57-8
5-methoxycarbamoyl methyl-2’-deoxyuridine

: 209163-81-5
5'-O-(4,4'-dimethoxytrityl)-5-cyanomethoxycarbonylmethyl-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent

2: 1.0 N lithium hydroxide / tetrahydrofuran / 1 h / Ambient temperature

3: 70 percent / potassium carbonate / hexamethylphosphoric acid triamide / 6 h / Ambient temperature

With lithium hydroxide; potassium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4039(98)00660-1