(5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate

Base Information

Chemical Name:(5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate
CAS No.:208254-12-0
Molecular Formula:C₃₁H₄₂O₅
Molecular Weight:494.671
Hs Code.:

Synonyms:(5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate

Suppliers and Price of (5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate

There total 8 articles about (5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 208833-68-5
(5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-hydroxypregnane-7,21-diol 7-benzoate

: 208254-12-0
(5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate

Guidance literature:: With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide; In water; ethyl acetate; at 0 - 5 ℃; pH=8 - 10;

Reference yield: 90.0%

: 208254-11-9
7α-benzoyloxy-3-dioxolane-5,6-dihydrostigmasterol

: 208254-12-0
(5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate

Guidance literature:: 7α-benzoyloxy-3-dioxolane-5,6-dihydrostigmasterol; With ozone; In ethanol; dichloromethane; Cooling with ethanol-dry ice;

With phosphorous acid trimethyl ester; In ethanol; dichloromethane; at 20 ℃; Cooling with ethanol-dry ice;

Reference yield:

: 83-48-7
Stigmasterol

: 208254-12-0
(5α,7α,20S)-3-spiro-2'-(1',3'-dioxolan)-20-methyl-21-oxopregnane-7-yl benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) N-hydroxyphthalimide, dibenzoyl peroxide, air, 2.) CuCl₂ / 1.) EtOAc, acetone, 50 - 55 deg C, 48 h, 2.) pyridine, 0 deg C, overnight

2: 1.) Li, NH₃, 2.) NH₄Cl / 1.) THF, 1 h, dry ice/acetone bath

3: 96 percent / K-selectride / tetrahydrofuran / -20 °C

4: 92 percent / Ag₂CO₃/celite / toluene / 8 h

5: 86 percent / DMAP / pyridine / 8 h / 0 - 20 °C

6: 95 percent / p-TsOH / toluene / 2 h / Heating

7: 1.) O₃, 2.) (MeO)3P / 1.) Ch₂Cl₂, EtOH, dry ice/ethanol bath, 2.) warm to room temperature

With dmap; N-hydroxyphthalimide; air; Celite; ammonia; lithium; potassium tri-sec-butyl-borohydride; ammonium chloride; toluene-4-sulfonic acid; ozone; silver carbonate; copper dichloride; phosphorous acid trimethyl ester; dibenzoyl peroxide; In tetrahydrofuran; pyridine; toluene;
DOI:10.1021/jo971405d