2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one

Base Information

• Chemical Name: 2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one
• CAS No.: 1287721-72-5
• Molecular Formula: C₂₃H₁₆ClN₃O₂S₂
• Molecular Weight: 465.984
• Mol file: 1287721-72-5.mol

Synonyms:2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one

Chemical Property of 2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one

There total 5 articles about 2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-(4-chlorophenyl)-2-furaldehyde (34035-03-5) + 3-(4-methylthiobenzyl)-1,2,4-triazole-5-thiol (1263796-97-9) + chloroacetic acid (79-11-8) → 2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one (1287721-72-5)

Guidance literature:

With sodium acetate; acetic anhydride; acetic acid; Reflux;

DOI:10.1080/10426507.2010.506454

Reference yield:

(4-methylthiophenyl)acetic acid hydrazide (1257393-74-0) → 2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one (1287721-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water / 5 h / Heating

2: sodium hydroxide / water / 3 h / Reflux

3: sodium acetate; acetic anhydride; acetic acid / Reflux

With hydrogenchloride; sodium acetate; acetic anhydride; acetic acid; sodium hydroxide; In water;

DOI:10.1080/10426507.2010.506454

Reference yield:

4-methylthiophenylacetyl thiosemicarbazide (1313870-47-1) → 2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one (1287721-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 3 h / Reflux

2: sodium acetate; acetic anhydride; acetic acid / Reflux

With sodium acetate; acetic anhydride; acetic acid; sodium hydroxide; In water;

DOI:10.1080/10426507.2010.506454

upstream raw materials:

(4-methylthiophenyl)acetic acid hydrazide

4-methylthiophenylacetyl thiosemicarbazide

5-(4-chlorophenyl)-2-furaldehyde

3-(4-methylthiobenzyl)-1,2,4-triazole-5-thiol