800391-48-4

Upstream product

• 800391-47-3 3-(tert-butyldiphenylsilanyloxy)-2-dibenzylamino-1-propanol 

Downstream Products

• 1095607-21-8 (2R,3S,4S)-2-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)-4-(dibenzylamino)-1-{(S)-2,2-dimethyl-1,3-dioxolan-4-yl}-3-hydroxypentan-1-one 
• 929006-91-7 (6S,7S)-6-(dibenzylamino)-2,2,13,13,14,14-hexamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadec-9-yn-7-ol 
• 929006-93-9 (3-(((4S,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)oxiran-2-yl)methanol 
• 929006-99-5 (2R,3R)-2-azido-4-((4S,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)butane-1,3-diol 
• 929007-01-2 (2S,3S)-2-azido-4-((4S,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)butane-1,3-diol 
• 929006-97-3 ((2S,3R)-3-(((4S,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)oxiran-2-yl)methanol 
• 929006-98-4 ((2R,3S)-3-(((4S,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)oxiran-2-yl)methanol 
• 929006-77-9 4-((4S,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)but-2-yn-1-ol 
• 929006-78-0 (E)-4-((4S,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)but-2-en-1-ol 
• 929006-79-1 (Z)-4-((4S,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)but-2-en-1-ol 
• 929006-92-8 (2S,3S)-2-(dibenzylamino)hept-5-yne-1,3,7-triol 
• 929006-76-8 (S)-N,N-dibenzyl-2-(tert-butyldiphenylsilyloxy)-1-((R)-oxiran-2-yl)ethanamine 

Relevant academic research and scientific papers

Aldol reactions between L-erythrulose derivatives and chiral α-amino and α-fluoro aldehydes: Competition between felkin-anh and cornforth transition states

Both matched and mismatched diastereoselection have been observed in aldol reactions of a boron enolate of a protected L-erythrulose derivative with several chiral α-fluoro and α-amino aldehydes. Strict adherence to the Felkin-Anh model for the respective transition structures does not account satisfactorily for all the observed results, as previously observed in the case of α-oxygenated aldehydes. In some cases, only the Cornforth model provides a good explanation. The factors that influence this dichotomy are discussed and a general mechanistic model is proposed for aldol reactions with α-heteroatom-substituted aldehydes. Additional support for the model was obtained from density functional calculations.

SYNTHESIS OF CHROMANONES

Processes for the preparation of biologically active chromanones are disclosed, including processes for the preparation of intermediates useful in the preparation of the biologically active chromanones. The chromanones and the intermediates disclosed herein may be useful for a variety of therapies, including the treatment of various cancers and the treatment of inflammation and inflammation related disorders.