3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate

Base Information

• Chemical Name: 3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate
• CAS No.: 1309387-63-0
• Molecular Formula: C₂₂H₁₈N₄O₃
• Molecular Weight: 386.41
• Mol file: 1309387-63-0.mol

Synonyms:3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate

Chemical Property of 3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate

There total 3 articles about 3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.6%

nicotinic acid (59-67-6) + C16H14BrN3O (1309387-62-9) → 3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate (1309387-63-0)

Guidance literature:

With triethylamine; In acetone; at 0 - 5 ℃; for 5h;

DOI:10.1016/j.saa.2011.02.040

Reference yield:

3-dimethylamino-m-methylpropiophenone hydrochloride (84498-31-7) → 3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate (1309387-63-0)

Guidance literature:

Multi-step reaction with 3 steps

2: bromine; sodium acetate / acetic acid / 8 h / 55 - 60 °C

3: triethylamine / acetone / 5 h / 0 - 5 °C

With bromine; sodium acetate; triethylamine; In acetic acid; acetone;

DOI:10.1016/j.saa.2011.02.040

Reference yield:

3-Methylacetophenone (585-74-0) → 3-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate (1309387-63-0)

Guidance literature:

Multi-step reaction with 4 steps

3: bromine; sodium acetate / acetic acid / 8 h / 55 - 60 °C

4: triethylamine / acetone / 5 h / 0 - 5 °C

With bromine; sodium acetate; triethylamine; In acetic acid; acetone;

DOI:10.1016/j.saa.2011.02.040

upstream raw materials:

nicotinic acid

C₁₆H₁₄BrN₃O

3-dimethylamino-m-methylpropiophenone hydrochloride

3-Methylacetophenone