4-(morpholinomethyl)phenylacetylene

Base Information

• Chemical Name: 4-(morpholinomethyl)phenylacetylene
• CAS No.: 933986-59-5
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.268
• Mol file: 933986-59-5.mol

Synonyms:4-(morpholinomethyl)phenylacetylene

Chemical Property of 4-(morpholinomethyl)phenylacetylene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-[(4-Ethynylphenyl)methyl]morpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(morpholinomethyl)phenylacetylene

There total 11 articles about 4-(morpholinomethyl)phenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-[4-(2-(trimethylsilyl)ethynyl)benzyl]morpholine (1093191-20-8) → 4-(morpholinomethyl)phenylacetylene (933986-59-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.carres.2012.06.006

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + (4-ethynylphenyl)methanol (10602-04-7) → 4-(morpholinomethyl)phenylacetylene (933986-59-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; (cyanomethyl)trimethyl-phosphonium iodide; In propiononitrile; for 16h; Reflux;

DOI:10.1016/j.bmcl.2008.10.039

Reference yield: 91.0%

morpholine (110-91-8,99108-56-2) + (4-ethynylphenyl)methyl methanesulfonate → 4-(morpholinomethyl)phenylacetylene (933986-59-5)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 12h;

upstream raw materials:

morpholine

(4-ethynylphenyl)methanol

4-Ethynylbenzaldehyde

4-[4-(2-(trimethylsilyl)ethynyl)benzyl]morpholine

Downstream raw materials:

(E)-4-(4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine

C₂₃H₂₃NO₄

(E)-methyl 4-(4-(4-(morpholinomethyl)phenyl)but-1-en-3-ynyl)benzoate

(S)-methyl 3-tert-butoxycarbonylamino-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanoate