1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol

Base Information

Chemical Name:1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol
CAS No.:1381932-15-5
Molecular Formula:C₂₂H₂₅BrN₄OS
Molecular Weight:473.437
Hs Code.:

Synonyms:1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol

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Chemical Property of 1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol

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Technology Process of 1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol

There total 6 articles about 1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 109-01-3
1-methyl-piperazine

: 1381932-21-3
1-(4-bromophenyl)-4-(oxiran-2-ylmethylthio)phthalazine

: 1381932-15-5
1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol

Guidance literature:: 1-(4-bromophenyl)-4-(oxiran-2-ylmethylthio)phthalazine; With potassium carbonate; potassium iodide; In acetonitrile; for 0.5h; Reflux;

1-methyl-piperazine; In acetonitrile; for 10h; Reflux;
DOI:10.1007/s00044-012-0099-6

Reference yield:

: 2159-40-2
2-(4-bromobenzoyl)benzoic acid

: 1381932-15-5
1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate

2.1: trichlorophosphate

3.1: ethanol / 3 h / Reflux

4.1: sodium hydroxide / 2 h / Reflux

5.1: sodium / ethanol / 0.5 h / Reflux

5.2: 25 °C

6.1: potassium carbonate; potassium iodide / acetonitrile / 0.5 h / Reflux

6.2: 10 h / Reflux

With sodium; potassium carbonate; hydrazine hydrate; potassium iodide; sodium hydroxide; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.1007/s00044-012-0099-6

Reference yield:

: 610276-13-6
4-(4-bromophenyl)phthalazine-1(2H)-thione

: 1381932-15-5
1-[4-(4-bromophenyl)phthalazin-1-ylthio]-3-(4-methylpiperazin-1-yl) propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium / ethanol / 0.5 h / Reflux

1.2: 25 °C

2.1: potassium carbonate; potassium iodide / acetonitrile / 0.5 h / Reflux

2.2: 10 h / Reflux

With sodium; potassium carbonate; potassium iodide; In ethanol; acetonitrile;
DOI:10.1007/s00044-012-0099-6