2159-40-2

Usage

InChI:InChI=1/C14H9BrO3/c15-10-7-5-9(6-8-10)13(16)11-3-1-2-4-12(11)14(17)18/h1-8H,(H,17,18)

Upstream product

• 85-44-9 phthalic anhydride 
• 108-86-1 bromobenzene 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 65565-21-1 3-(4-bromophenyl)-2,3-dihydro-1H-inden-1-one 
• 64-19-7 acetic acid 
• 65799-42-0 2-bromo-3-(4-bromo-phenyl)-indan-1-one 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 65-85-0 benzoic acid 

Downstream Products

• 32017-71-3 methyl 2-(4-bromobenzoyl)benzoate 
• 76633-67-5 3-(4-Bromo-phenyl)-3-(2,4,6-trihydroxy-phenyl)-3H-isobenzofuran-1-one 
• 127828-85-7 [4-(4-Bromo-phenyl)-1-oxo-1H-phthalazin-2-yl]-acetic acid ethyl ester 
• 76462-38-9 4-(4-bromophenyl)-1,2-dihydrophthalazin-1-ol 
• 76619-41-5 Acetic acid 1-(4-bromo-phenyl)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester 
• 76619-47-1 3-(4-Bromo-phenyl)-3-(2,3-dihydroxy-phenyl)-3H-isobenzofuran-1-one 
• 76619-49-3 3-(4-Bromo-phenyl)-3-(2,5-dihydroxy-phenyl)-3H-isobenzofuran-1-one 
• 76462-37-8 4-(4-bromo-phenyl)-2-phenyl-2H-phthalazin-1-one 
• 76619-45-9 p-Bromophenyl resorcinolphthal-as-ein 
• 76619-51-7 3-(4-Bromo-phenyl)-3-(2,3,4-trihydroxy-phenyl)-3H-isobenzofuran-1-one 
• 76619-43-7 3-(4-Bromo-phenyl)-3-(4-hydroxy-phenyl)-3H-isobenzofuran-1-one 
• 76619-38-0 3-(4-Bromo-phenyl)-3-(3,5-dibromo-2,4-dihydroxy-phenyl)-3H-isobenzofuran-1-one 
• 76619-36-8 Acetic acid 5-acetoxy-2-[1-(4-bromo-phenyl)-3-oxo-1,3-dihydro-isobenzofuran-1-yl]-phenyl ester 
• 134949-75-0 2-methyl-4-(4-bromophenyl)-1-(2H)-phthalazinone 

Relevant academic research and scientific papers

The novel synthesis of tris-cyclometalated iridium(III) complexes for saturated red organic light-emitting diodes with low efficiency roll-off

A series of homoleptic tris-cyclometalated iridium(III) complexes (Ir2–Ir4) have been synthesized by the direct functionalization of a template complex (Ir1) through a Suzuki cross-coupling reaction. We revealed the coordination arrangement of Ir4 by single X-ray structural analysis and the molecule showed a facial configuration. All the complexes showed red emission with emission maxima at 591–624 nm, short lifetimes of 1.38–2.19 μs and photoluminescence quantum yields in the range of 28–42%. Most importantly, the full width at half maximum (FWHM) of the emission maxima of these complexes was less than 48 nm. These complexes exhibited good thermal stability with Td of 368–400 °C. Density functional theory (DFT) calculations were used to study the electronic structure information of these iridium(III) complexes. Organic light emitting diodes (OLEDs) based on these complexes as dopant emissive materials were fabricated. Among them the device based on Ir1 has a maximum current efficiency and external quantum efficiency of 15.67 cd A?1 and 10.06%, respectively. The device with low efficiency and EQE roll-off that 97–99% efficiency and EQEmax maintained at 1000 cd m?2. Meanwhile, the CIE(x,y) coordinates of these extended complexes were (0.65, 0.33), (0.66, 0.33) and (0.68, 0.31), respectively. These data were very close to the standard red emission required by National Television System Committee (NTSC) (0.67, 0.33). These results suggest that these materials have potential application in OLEDs.

COMPOUNDS WITH ANTIMICROBIAL ACTIVITY

Provided herein are compounds useful in the treatment of bacterial infections, pharmaceuticals comprising the same, and methods of use and preparation thereof.

Discovery of Antibacterials That Inhibit Bacterial RNA Polymerase Interactions with Sigma Factors

Formation of a bacterial RNA polymerase (RNAP) holoenzyme by a catalytic core RNAP and a sigma (σ) initiation factor is essential for bacterial viability. As the primary binding site for the housekeeping σ factors, the RNAP clamp helix domain represents an attractive target for novel antimicrobial agent discovery. Previously, we designed a pharmacophore model based on the essential amino acids of the clamp helix, such as R278, R281, and I291 (Escherichia coli numbering), and identified hit compounds with antimicrobial activity that interfered with the core-σ interactions. In this work, we rationally designed and synthesized a class of triaryl derivatives of one hit compound and succeeded in drastically improving the antimicrobial activity against Streptococcus pneumoniae, with the minimum inhibitory concentration reduced from 256 to 1 μg/mL. Additional characterization of antimicrobial activity, inhibition of transcription, in vitro pharmacological properties, and cytotoxicity of the optimized compounds demonstrated their potential for further development.

Naked eye detection of anions by 2,2¤-bianthracene derivative bearing urea groups in various organic solvents

A highly fluorescent 2,2¤-bianthryl derivative bearing urea groups (2) was prepared as an anion receptor. The UV-vis and fluorescence titrations of 2 in various organic solvents revealed that the association constants (K11) were correlated with acceptor number and Swain acity of the solvents used, and tetrahydrofuran was found to strongly enhance the K11 for Cl1 and AcO1 due to enthalpy driven complexation, in which naked eye detection of AcO1 was achieved.

A facile greener synthesis, antimicrobial evaluation and molecular modelling of new 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-one derivatives

Abstract: The synthesis of 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-ones was performed by cyclization of 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine with 2-aroylbenzoic acids in ethanol containing a catalytic amount of concentrated sulfuric acid under solid state conditions. All these synthesized compounds (8a–h) were screened for their in vitro antibacterial activity against gram-positive bacteria such as (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli) and also evaluated for their antifungal activity against Aspergillus Niger and Helmenthosphorium oryzae fungal strains. Some of the products demonstrate good antibacterial activity and moderate antifungal activity. In predominantly, 8b, 8d, 8g, and 8h compounds showed good to excellent antibacterial and antifungal activities. The antimicrobial activity of the compound 8 was further investigated with the help of in LibDock score docking study to predict the active sites. Graphical abstract: [Figure not available: see fulltext.].

Method for preparation of 10, 10-bisubstituted-3-bromo anthrone

The invention provides a method for the preparation of 10, 10-bisubstituted-3-bromo anthrone, and belongs to the field of organic chemistry. According to the method, phthalic anhydride and bromobenzene are used as raw materials, the raw materials are sequentially subjected to a ring opening reaction, a reduction reaction, an esterification reaction, a tert alcoholization reaction, a cyclization reaction and an oxidation reaction, and 10, 10-bisubstituted-3-bromo anthrone is obtained. The raw materials in the method are cheap and easily obtained, reaction conditions are simple, and the tolerance to a bromine-containing functional group is good.

Synthesis and Biological Evaluation of New Phthalazinone Derivatives as Anti-Inflammatory and Anti-Proliferative Agents

The chemistry of phthalazine derivatives has been of increasing interest since many of these compounds have found many chemotherapeutic applications. So this study aims to synthesize a library of phthalazine derivatives and to investigate their anti-inflammatory and anti-proliferative activities. Sixteen new phthalazinone derivatives (2a-p) were synthesized and tested for their in vitro antiproliferative and in vivo anti-inflammatory activities. All the synthesized compounds were identified and characterized by IR, 1H NMR, 13C NMR spectroscopy, and MS. Two compounds, 2b and 2i, showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib in the carrageenan-induced rat paw edema model at 3 and 5 h, respectively. Three compounds (2h, 2j, and 2g) showed moderate sensitivity toward the renal cancer cell line UO-31. A library of new phthalazone compounds (2a-p) was synthesized as dual inhibitors (COX-2/LOX-5) and evaluated for their anti-inflammatory, anticancer activities. Two compounds showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib, whereas three compounds showed moderate sensitivity toward the renal cancer cell line UO-31.

Antiaromatic compounds and organic light-emitting device comprising the same

The present invention relates to an anti-aromatic compound and an organic light emitting device comprising the same. According to one embodiment of the present invention, provided is an anti-aromatic compound represented by chemical formula 1. The organic light emitting device comprising the anti-aromatic compound can obtain high efficiency and long lifespan properties.COPYRIGHT KIPO 2016

Synthesis and biological evaluation of 4-arylphthalazones bearing benzenesulfonamide as anti-inflammatory and anti-cancer agents

Nine 4-arylphthalazones bearing benzenesulfonamide (2a-i) were synthesized by the condensation of the appropriate 2-aroylbenzoic acid (1a-i) and 4-hydrazinobenzenesulfonamide in ethanol. The structures of these compounds were elucidated by elemental analysis, IR, 1H NMR, 13C NMR, and MS spectroscopy. Two compounds, 2b and 2i, showed significant anti-inflammatory activity comparable to that of the standard drug celecoxib in the carrageenan-induced rat paw edema model. These compounds (2b and 2i) had selective inhibitory activity towards the COX-2 enzyme. Compound 2b had a better selectivity ratio (COX-1/COX-2) compared to that of celecoxib and can be used as a novel template for the design of selective COX-2 inhibitors. Compounds 2d and 2i were screened for their antiproliferative activity toward 60 human cancer cell lines by the National Cancer Institute (USA). The compounds 2d and 2i displayed mild activity toward the renal cancer cell line UO-31. Nine 4-arylphthalazones bearing benzenesulfonamide (2a-i) were synthesized by the condensation of the appropriate 2-aroylbenzoic acid (1a-i) and 4-hydrazinobenzenesulfonamide in ethanol. Compounds 2b and 2i showed anti-inflammatory activity comparable to that of celecoxib in the carrageenan-induced rat paw edema model. Compounds 2d and 2i were screened for their antiproliferative activity towards 60 human cancer cell lines, displaying mild activity toward the renal cancer cell line UO-31. Copyright

Palladium-catalyzed chemoselective decarboxylative ortho acylation of benzoic acids with α-oxocarboxylic acids

Palladium-catalyzed chemoselective decarboxylative cross coupling of benzoic acids with α-oxocarboxylic acids was realized via an arene sp 2 C-H functionalization process. This work represents the first example of transition-metal-catalyzed cro