4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid

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Chemical Name:4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid
CAS No.:667931-65-9
Molecular Formula:C₂₈H₃₄N₄O₃
Molecular Weight:474.603
Hs Code.:

Synonyms:4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid

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Chemical Property of 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid

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Technology Process of 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid

There total 14 articles about 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 683745-75-7
ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate

: 667931-65-9
4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid

Guidance literature:: ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate; With sodium hydroxide; In ethanol; at 60 ℃; for 12h;

With hydrogenchloride; In water; ethyl acetate;
DOI:10.1016/j.bmc.2011.02.001

Reference yield:

: 667920-89-0,667930-75-8,667930-76-9
ethyl 2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate

: 667931-65-9
4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: CHIRALCEL OD / ethanol; hexane / 30 °C / Resolution of racemate

2.1: potassium hydroxide / ethanol; water / 16 h / 90 °C

2.2: pH 4

3.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 1 h / 20 °C

4.1: triethylamine / toluene / 3 h / 70 °C

5.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / 24 h / 90 °C

6.1: sodium hydroxide / ethanol / 12 h / 60 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; palladium diacetate; triethylamine; potassium hydroxide; sodium hydroxide; In ethanol; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.02.001

Reference yield:

: 1293345-01-3
ethyl (5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate

: 667931-65-9
4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 16 h / 90 °C

1.2: pH 4

2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 1 h / 20 °C

3.1: triethylamine / toluene / 3 h / 70 °C

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / 24 h / 90 °C

5.1: sodium hydroxide / ethanol / 12 h / 60 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; palladium diacetate; triethylamine; potassium hydroxide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.02.001