ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate

Base Information

Chemical Name:ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate
CAS No.:683745-75-7
Molecular Formula:C₃₀H₃₈N₄O₃
Molecular Weight:502.657
Hs Code.:

Synonyms:ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate

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Chemical Property of ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate

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Technology Process of ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate

There total 12 articles about ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 71080-92-7
carbon monoxide

: 64-17-5
ethanol

: 683203-70-5
(5R)-N-[1-ethyl-1-(4-iodophenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

: 683745-75-7
ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; at 90 ℃; for 24h;
DOI:10.1016/j.bmc.2011.02.001

Reference yield:

: 667920-89-0,667930-75-8,667930-76-9
ethyl 2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate

: 683745-75-7
ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: CHIRALCEL OD / ethanol; hexane / 30 °C / Resolution of racemate

2.1: potassium hydroxide / ethanol; water / 16 h / 90 °C

2.2: pH 4

3.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 1 h / 20 °C

4.1: triethylamine / toluene / 3 h / 70 °C

5.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / 24 h / 90 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; palladium diacetate; triethylamine; potassium hydroxide; In ethanol; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.02.001

Reference yield:

: 1293345-01-3
ethyl (5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate

: 683745-75-7
ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 16 h / 90 °C

1.2: pH 4

2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 1 h / 20 °C

3.1: triethylamine / toluene / 3 h / 70 °C

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / 24 h / 90 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; palladium diacetate; triethylamine; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.02.001