Welcome to LookChem.com Sign In|Join Free
  • or

Encyclopedia

Penbritin-S

Base Information Edit
  • Chemical Name:Penbritin-S
  • CAS No.:69-53-4
  • Molecular Formula:C16H19N3O4S
  • Molecular Weight:363.437
  • Hs Code.:29212900
  • Mol file:69-53-4.mol
Penbritin-S

Synonyms:Binotal sodium;Sodium binotal;Totacillin-N;Penbritin-S;Principen/N;Omnipen-N;Amcill-S;Alpen-N;Sodium P-50;(2S,5R,6R)-6-[[(2R)-2-azaniumyl-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;PEN A/N;C16H19N3O4S.Na;DRG-0074;C16-H19-N3-O4-S.Na;EINECS 200-708-1;4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, monosodium salt, (2S-(2alpha,5alpha,6beta(S*)))-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-[2alpha,5alpha,6beta(S*)]]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, monosodium salt,[2S-[2.alpha.,5.alpha.,6.beta.(S*)]]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-;Monosodium (2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate;natrium-[2S-[2alpha,5alpha,6beta(S*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat;Sodium [2S-[2alpha,5alpha,6beta(S*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Suppliers and Price of Penbritin-S
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • DDO
  • 100ul
  • $ 499.00
  • TRC
  • Ampicillin
  • 1g
  • $ 65.00
  • TRC
  • Ampicillin
  • 100mg
  • $ 55.00
  • Sigma-Aldrich
  • Ampicillin United States Pharmacopeia (USP) Reference Standard
  • 200mg
  • $ 366.00
  • Sigma-Aldrich
  • Ampicillin anhydrous, 96.0-100.5% (anhydrous basis)
  • 25g
  • $ 295.00
  • Sigma-Aldrich
  • Ampicillin
  • 10835269001
  • $ 265.00
  • Sigma-Aldrich
  • Ampicillin meets USP testing specifications
  • 25 g
  • $ 193.00
  • Sigma-Aldrich
  • Ampicillin anhydrous, European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Ampicillin anhydrous, European Pharmacopoeia (EP) Reference Standard
  • a1000000
  • $ 190.00
  • Sigma-Aldrich
  • Ampicillin analytical standard
  • 100mg
  • $ 42.30
Total 196 raw suppliers
Chemical Property of Penbritin-S Edit
Chemical Property:
  • Appearance/Colour:Crystalline solid 
  • Melting Point:198-200 °C (dec.)(lit.) 
  • Refractive Index:1.6320 (estimate) 
  • Boiling Point:683.9 °C at 760 mmHg 
  • PKA:2.5 (COOH)(at 25℃) 
  • Flash Point:367.4 °C 
  • PSA:138.03000 
  • Density:1.45 g/cm3 
  • LogP:1.34720 
  • Storage Temp.:2-8°C 
  • Solubility.:NH4OH 1 M: 50 mg/mL, clear, colorless 
  • Water Solubility.:0.1-1 g/100 mL at 21℃ 
  • XLogP3:-0.5
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:3
  • Exact Mass:349.10962727
  • Heavy Atom Count:24
  • Complexity:556
Purity/Quality:

99%, *data from raw suppliers

DDO *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn 
  • Hazard Codes:Xn,T 
  • Statements: 36/37/38-42/43-61 
  • Safety Statements: 22-26-36/37-45-53 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)[NH3+])C(=O)[O-])C
  • Isomeric SMILES:CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)[NH3+])C(=O)[O-])C
  • Description Ampicillin is an antibacterial antibiotic from the α-aminobenzyl penicillin group, which differs from penicillin by the presence of an amino group that facilitates penetration through the outer membrane of some gram-negative bacteria. Ampicillin is Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria. Ampicillin is a β-lactam antibiotic within the penicillin family. As a member of this family, Ampicillin is susceptible to β-lactamase, which hydrolyzes the β-lactam ring. This broad spectrum antibiotic is effective against gram-positive, gram-negative bacteria and anaerobic bacteria. Ampicillin is widely used in cell culture as a selective agent. As an antibiotic, Ampicillin binds to penicillin binding proteins (PBPs) on a susceptible organism and Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. After binding to the PBPs, Ampicilin acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and thereby prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium. Ampicillin sodium can be used as a selective agent in several types of isolation media. Ampicillin sodium is routinely used to select for cells containing the pcDNA3.1 and pEAK10 resistance plasmids in cell line A904L at an effective concentration of 50 μg/ml.
  • Uses Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin), and in a pharmaceutical factory worker. β-lactam antibiotics Labelled Ampicillin. Orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.
  • Therapeutic Function Antibacterial
Technology Process of Penbritin-S

There total 31 articles about Penbritin-S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With (S)-Phenylglycine methyl ester; In ethylene glycol; at 20 ℃; for 48h; Enzymatic reaction;
DOI:10.1016/j.cclet.2010.02.015
Guidance literature:
With A. faecalis; immobilised penicillin acylase (EC 3.5.1.11); In water; acetonitrile; at 0 ℃; Further Variations:; Solvents; reusing run; Product distribution; Kinetics; Enzymatic reaction;
DOI:10.1002/adsc.200303023
Guidance literature:
With phosphate buffer; Eupergit C-immobilized penicillin acylase (30 U/mg); sodium sulfate; at 20 ℃; pH=6.5; Further Variations:; Reagents; water content; Product distribution; Kinetics; solid phase reaction;
DOI:10.1002/1615-4169(200209)344:8<894::AID-ADSC894>3.0.CO;2-Q
Post RFQ for Price