(9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Base Information

• Chemical Name: (9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine
• CAS No.: 667456-04-4
• Molecular Formula: C₇₀H₆₀FN₅O₆
• Molecular Weight: 1086.27

Synonyms:(9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Chemical Property of (9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

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Technology Process of (9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

There total 4 articles about (9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

Trifluoro-methanesulfonic acid (2R,3R,4R,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester (667456-01-1) → (9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine (667456-04-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In acetonitrile; at 72 - 74 ℃; for 0.5h;

DOI:10.1002/jlcr.712

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → (9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine (667456-04-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / dimethylaminopyridine; pyridine / 18 h / 85 - 88 °C

2: 90 percent / pyridine / 0.67 h / 0 - 20 °C

3: 50 percent / n-Bu₄NF / acetonitrile / 0.5 h / 72 - 74 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; In acetonitrile;

DOI:10.1002/jlcr.712

Reference yield:

adenosine (58-61-7) → (9-{(2R,3S,4S,5R)-4-Fluoro-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine (667456-04-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / dimethylaminopyridine; pyridine / 18 h / 85 - 88 °C

2: 90 percent / pyridine / 0.67 h / 0 - 20 °C

3: 50 percent / n-Bu₄NF / acetonitrile / 0.5 h / 72 - 74 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; In acetonitrile;

DOI:10.1002/jlcr.712

upstream raw materials:

Trifluoro-methanesulfonic acid (2R,3R,4R,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester

mono-4-methoxytrityl chloride

adenosine

N₆-[(4-methoxyphenyl)(diphenyl)methyl]-2',5'-bis-O-[(4-methoxyphenyl)(diphenyl)methyl]adenosine

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