3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide

Base Information

Chemical Name:3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide
CAS No.:1124216-63-2
Molecular Formula:C₂₃H₂₇FN₄O₂
Molecular Weight:410.491
Hs Code.:

Synonyms:3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide

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Chemical Property of 3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide

Chemical Property:

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Technology Process of 3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide

There total 3 articles about 3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124216-61-0
N-cyclobutyl-3-(piperazin-1-ylmethyl)benzamide

: 455-87-8
4-amino-3-fluorobenzoic acid

: 1124216-63-2
3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; ethyl acetate; for 1h;

Reference yield:

: 1124216-59-6
3-(chloromethyl)-N-cyclobutylbenzamide

: 1124216-63-2
3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / sodium iodide / acetonitrile / 3 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 24 h

3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane; ethyl acetate / 1 h

With potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 1124216-57-4
tert-butyl 4-(3-(cyclobutylcarbamoyl)benzyl)piperazine-1-carboxylate

: 1124216-63-2
3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 24 h

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane; ethyl acetate / 1 h

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate;