N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide

Base Information

• Chemical Name: N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide
• CAS No.: 1286264-63-8
• Molecular Formula: C₂₉H₃₉Cl₂N₅O₅S
• Molecular Weight: 640.631

Synonyms:N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide

Chemical Property of N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide

Chemical Property:

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Technology Process of N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide

There total 11 articles about N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-[methyl(piperidin-4-yl)amino]-2-oxoethyl}-N1-(2-pyrrolidin-1-ylethyl)glycinamide + methanesulfonyl chloride (124-63-0) → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N1-(2-pyrrolidin-1-ylethyl)glycinamide (1286264-63-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2015.05.018

Reference yield:

N-[5-chloro-2-(4-chlorophenoxy)phenyl]iminodiacetic acid diethyl ester → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N1-(2-pyrrolidin-1-ylethyl)glycinamide (1286264-63-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide; water / methanol; tetrahydrofuran / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

3: 0 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 0 - 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.06.008

Reference yield:

N-[5-chloro-2-(4-chlorophenoxy)phenyl]iminodiacetic acid → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N1-(2-pyrrolidin-1-ylethyl)glycinamide (1286264-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: 0 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.06.008

upstream raw materials:

1-(2-aminoethyl)pyrrolidine

2,5-dichloronitrobenzene

4-chloro-phenol

4-chloro-1-(4-chlorophenoxy)-2-nitrobenzene

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