2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride

Base Information

Chemical Name:2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride
CAS No.:159493-46-6
Molecular Formula:C₁₆H₂₁Cl₃FNO₇
Molecular Weight:464.703
Hs Code.:

Synonyms:2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride

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Chemical Property of 2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride

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Technology Process of 2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride

There total 2 articles about 2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 538-75-0
dicyclohexyl-carbodiimide

: 159493-46-6
2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 4.5 h / Heating

2: 1.) Ac₂O, HF / 1.) 0,5 h, 0 deg C, 2.) MeNO₂, 5 h, room t.

With hydrogen fluoride; acetic anhydride; In 1,2-dichloro-ethane;
DOI:10.1055/s-1994-25583

Reference yield:

: 159493-45-5
Methyl 6-O-formyl-2-O-(cyclohexylcarbamoyl)-3,4-O-(2,2,2-trichloroethylidene)-α-D-altropyranoside

: Formic acid (2R,3aR,4R,6R,7S,7aR)-7-cyclohexylcarbamoyloxy-6-fluoro-2-trichloromethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester

: 159493-46-6
2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride

Guidance literature:: With hydrogen fluoride; acetic anhydride; Yield given. Multistep reaction. Title compound not separated from byproducts; 1.) 0,5 h, 0 deg C, 2.) MeNO₂, 5 h, room t.;
DOI:10.1055/s-1994-25583

Reference yield: 84.0%

: 159493-46-6
2-O-cyclohexylcarbamoyl-6-O-formyl-<(R)-3,4-O-(2,2,2-trichloroethylidene)>-α-D-altropyranosyl fluoride

: Cyclohexyl-carbamic acid (1R,2R,4S,6R,7S,8R)-4-trichloromethyl-3,5,9,11-tetraoxa-tricyclo[6.2.1.0^2,6]undec-7-yl ester

Guidance literature:: With boron trifluoride diethyl etherate; triethylamine; In diethyl ether; dichloromethane; for 48h; Ambient temperature;