5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile

Base Information

Chemical Name:5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile
CAS No.:1060726-68-2
Molecular Formula:C₂₂H₂₃Cl₂N₅O
Molecular Weight:444.364
Hs Code.:

Synonyms:5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile

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Chemical Property of 5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile

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Technology Process of 5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile

There total 9 articles about 5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1060726-55-7
(E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

: 1060726-68-2
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile

Guidance literature:: With acetic anhydride; for 8h; Product distribution / selectivity; Heating / reflux;

Reference yield: 72.0%

: 1060726-57-9
(s-trans) 5-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy]pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

: 1060726-68-2
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile

Guidance literature:: With acetic anhydride; for 8h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 156969-42-5
pyrazolo<1,5-a>pyridin-5-ol

: 1060726-68-2
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

2.1: sodium iodide / acetonitrile / 0.5 h / Reflux; Inert atmosphere

2.2: 5 h / 85 °C / Inert atmosphere

3.1: trichlorophosphate / 1 h / 20 °C / Inert atmosphere

3.2: Cooling; Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium hydroxide; hydrogenchloride / water; ethanol / 2 h / pH 5 / Reflux; Inert atmosphere

5.1: acetic anhydride / 8 h / Reflux; Inert atmosphere

With hydrogenchloride; hydroxylamine hydrochloride; potassium carbonate; sodium iodide; sodium hydroxide; trichlorophosphate; In ethanol; water; acetic anhydride; N,N-dimethyl-formamide; acetonitrile; 3.1: |Vilsmeier Reaction / 3.2: |Vilsmeier Reaction;
DOI:10.1021/jm5004039