(E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

Base Information

Chemical Name:(E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime
CAS No.:1060726-55-7
Molecular Formula:C₂₂H₂₅Cl₂N₅O₂
Molecular Weight:462.379
Hs Code.:

Synonyms:(E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

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Chemical Property of (E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

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Technology Process of (E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

There total 7 articles about (E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1060725-77-0
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde

: 1060726-55-7
(E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

Guidance literature:: With hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; In ethanol; water; at 0 ℃; for 2h; pH=5; Heating / reflux;

Reference yield:

: 1060725-03-2
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine

: 1060726-55-7
(E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 1 h / 20 °C / Inert atmosphere

1.2: Cooling; Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium hydroxide; hydrogenchloride / water; ethanol / 2 h / pH 5 / Reflux; Inert atmosphere

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydroxide; trichlorophosphate; In ethanol; water; 1.1: |Vilsmeier Reaction / 1.2: |Vilsmeier Reaction;
DOI:10.1021/jm5004039

Reference yield:

: 156969-42-5
pyrazolo<1,5-a>pyridin-5-ol

: 1060726-55-7
(E)-5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

2.1: sodium iodide / acetonitrile / 0.5 h / Reflux; Inert atmosphere

2.2: 5 h / 85 °C / Inert atmosphere

3.1: trichlorophosphate / 1 h / 20 °C / Inert atmosphere

3.2: Cooling; Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium hydroxide; hydrogenchloride / water; ethanol / 2 h / pH 5 / Reflux; Inert atmosphere

With hydrogenchloride; hydroxylamine hydrochloride; potassium carbonate; sodium iodide; sodium hydroxide; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; 3.1: |Vilsmeier Reaction / 3.2: |Vilsmeier Reaction;
DOI:10.1021/jm5004039