<1-¹³C>-3-Benzyloxycarbonylaminopropionitrile

Base Information

• Chemical Name: <1-¹³C>-3-Benzyloxycarbonylaminopropionitrile
• CAS No.: 134307-73-6
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 205.217
• Mol file: 134307-73-6.mol

Synonyms:<1-¹³C>-3-Benzyloxycarbonylaminopropionitrile

Chemical Property of <1-¹³C>-3-Benzyloxycarbonylaminopropionitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of <1-¹³C>-3-Benzyloxycarbonylaminopropionitrile

There total 1 articles about <1-¹³C>-3-Benzyloxycarbonylaminopropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

[13C]-potassium cyanide (25909-68-6) + 2-(((benzyloxy)carbonyl)amino)ethyl 1-methanesulfonate (134307-72-5) → <1-13C>-3-Benzyloxycarbonylaminopropionitrile (134307-73-6)

Guidance literature:

In dimethyl sulfoxide; for 120h; Ambient temperature;

DOI:10.1039/c39880001234

Reference yield: 97.0%

<1-13C>-3-Benzyloxycarbonylaminopropionitrile (134307-73-6) → <1-13C>-N-Benzyloxycarbonyl-β-Alanine (134307-74-7)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In methanol; water; for 48h; Ambient temperature;

DOI:10.1039/c39880001234

Reference yield:

<1-13C>-3-Benzyloxycarbonylaminopropionitrile (134307-73-6) → C10(13)CH14BrNO2

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / NaOH, 30percent H₂O₂ / methanol; H₂O / 48 h / Ambient temperature

2: 85 percent / ClCO₂Et, NEt₃, NaBH₄ / tetrahydrofuran / -10 °C

3: 83 percent / CBr₄, Ph₃P / CH₂Cl₂ / 1 h / -10 °C

With sodium hydroxide; sodium tetrahydroborate; carbon tetrabromide; dihydrogen peroxide; chloroformic acid ethyl ester; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1039/c39880001234

upstream raw materials:

[¹³C]-potassium cyanide

2-(((benzyloxy)carbonyl)amino)ethyl 1-methanesulfonate

Downstream raw materials:

<1-¹³C>-N-Benzyloxycarbonyl-β-Alanine

[1-⁽¹³⁾C]-3-[(benzyloxycarbonyl)amino]propanol