134307-74-7Relevant academic research and scientific papers
EXPERIMENTS AND SPECULATIONS ON THE ROLE OF OXIDATIVE CYCLIZATION CHEMISTRY IN NATURAL PRODUCT BIOSYNTHESIS
Townsend, Craig A.,Basak, Amit
, p. 2591 - 2602 (2007/10/02)
Syntheses of 2H,3-13C>- and 2H,3'-2H2>proclavaminic acid, (22) and (29) respectively, are described.These labeled substrates were incubated with clavaminate synthase, a key emzyme acting in the biosynthesi
The Role of Molecular Oxygen in Clavulanic Acid Biosynthesis: Evidence for a Bacterial Oxidative Deamination
Townsend, Craig A.,Krol, Walter J.
, p. 1234 - 1236 (2007/10/02)
Growth of cultures of Streptomyces clavuligerus (ATCC 27064) in an 18O2-containing atmosphere resulted in efficient and equal incorporations of molecular oxygen into the oxazolidine ring and the allylic hydroxy group of clavulanic acid.
