Technology Process of (1S,2R)-3-azido-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol
There total 5 articles about (1S,2R)-3-azido-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H24O5SSi;
With
tetrabutyl ammonium fluoride;
With
sodium azide;
2-Ethoxyphenol;
With
sodium hydroxide;
DOI:10.1016/j.tetasy.2012.04.018
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C
2: AD-mix α; methanesulfonamide; water / tert-butyl alcohol / 9.5 h / 0 °C
3: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C
4: sodium periodate; ruthenium(III) chloride trihydrate / tetrachloromethane; water; acetonitrile / 1 h / 0 °C
5: tetrabutyl ammonium fluoride
With
1H-imidazole; sodium periodate; thionyl chloride; methanesulfonamide; ruthenium(III) chloride trihydrate; AD-mix α; tetrabutyl ammonium fluoride; water; triethylamine;
In
tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetasy.2012.04.018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: AD-mix α; methanesulfonamide; water / tert-butyl alcohol / 9.5 h / 0 °C
2: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C
3: sodium periodate; ruthenium(III) chloride trihydrate / tetrachloromethane; water; acetonitrile / 1 h / 0 °C
4: tetrabutyl ammonium fluoride
With
sodium periodate; thionyl chloride; methanesulfonamide; ruthenium(III) chloride trihydrate; AD-mix α; tetrabutyl ammonium fluoride; water; triethylamine;
In
tetrachloromethane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetasy.2012.04.018
