N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester

Base Information

Chemical Name:N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester
CAS No.:205748-77-2
Molecular Formula:C₃₁H₃₁N₅O₁₄
Molecular Weight:697.612
Hs Code.:

Synonyms:N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester

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Chemical Property of N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester

Chemical Property:

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Technology Process of N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester

There total 8 articles about N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 107-14-2
chloroacetonitrile

: 205748-75-0
N,N'-di-NVOC-(S)-α-hydrazinophenylalanine

: 205748-77-2
N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester

Guidance literature:: With triethylamine; In acetonitrile; at 25 ℃; for 15h;
DOI:10.1021/ja974066e

Reference yield:

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 205748-77-2
N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / tetrahydrofuran

2: 2,6-lutidine / CH₂Cl₂ / 1.5 h / 0 °C

3: CH₂Cl₂ / 19 h / 0 - 20 °C

4: aq. CF₃CO₂H / CH₂Cl₂ / 2 h / 0 °C

5: 1N aq. NaOH / methanol / 2 h / 0 - 20 °C

6: 33 percent / aq. Na₂CO₃ / dioxane / 5 h / 25 °C

7: 61 percent / Et₃N / acetonitrile / 15 h / 25 °C

With 2,6-dimethylpyridine; sodium hydroxide; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja974066e

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 205748-77-2
N,N'-di-NVOC-(S)-α-hydrazinophenylalanine cyanomethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 42 percent / aq. HCl, aq. H₂SO₄, NaNO₂ / CHCl₃ / 6 h / 0 °C

2: 80 percent / tetrahydrofuran

3: 2,6-lutidine / CH₂Cl₂ / 1.5 h / 0 °C

4: CH₂Cl₂ / 19 h / 0 - 20 °C

5: aq. CF₃CO₂H / CH₂Cl₂ / 2 h / 0 °C

6: 1N aq. NaOH / methanol / 2 h / 0 - 20 °C

7: 33 percent / aq. Na₂CO₃ / dioxane / 5 h / 25 °C

8: 61 percent / Et₃N / acetonitrile / 15 h / 25 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; sulfuric acid; sodium carbonate; triethylamine; trifluoroacetic acid; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1021/ja974066e