2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine

Base Information

• Chemical Name: 2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine
• CAS No.: 1201186-50-6
• Molecular Formula: C₁₆H₁₆BrN₃O₂S
• Molecular Weight: 394.292
• Mol file: 1201186-50-6.mol

Synonyms:2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine

Chemical Property of 2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine

There total 1 articles about 2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-tert-butylbenzenesulfonyl chloride (15084-51-2) + 2-bromo-5H-pyrrolo[2,3-b]pyrazine (875781-43-4) → 2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine (1201186-50-6)

Guidance literature:

2-bromo-5H-pyrrolo[2,3-b]pyrazine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h;

4-tert-butylbenzenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 10 ℃; for 2h;

Reference yield: 87.0%

t-butoxycarbonylhydrazine (870-46-2) + 2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine (1201186-50-6) → 5-(4-tert-butylphenylsulfonyl)-2-hydrazinyl-5H-pyrrolo[2,3-b]pyrazine (1201186-53-9)

Guidance literature:

t-butoxycarbonylhydrazine; 2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine; With sodium t-butanolate; tert-butyl XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 5.5h;

With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 1h;

With sodium hydrogencarbonate; In water;

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) + 2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine (1201186-50-6) → tert-butyl 1-(5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)hydrazinecarboxylate (1201186-52-8) + tert-butyl 2-(5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)hydrazinecarboxylate (1201186-51-7)

Guidance literature:

With sodium t-butanolate; tert-butyl XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 5.5h;

upstream raw materials:

4-tert-butylbenzenesulfonyl chloride

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Downstream raw materials:

tert-butyl 1-(5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)hydrazinecarboxylate

tert-butyl 2-(5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)hydrazinecarboxylate

5-(4-tert-butylphenylsulfonyl)-2-hydrazinyl-5H-pyrrolo[2,3-b]pyrazine